In recent years, the 5-year survival rate of people with tumors in China has significantly increased. This improvement in survival rate can be attributed to the promotion of tumor screening and multidisciplinary comprehensive treatment, the implementation of precision oncology, and continuous innovation in new drug research and development. However, the continuous update of drug delivery materials has also enhanced the effectiveness of drugs. This preview focuses on nanomaterial microneedles (MNs) extracted from nature-an effective, minimally invasive delivery platform suitable for various drugs and sensors in different target tissues. They are capable of targeting drug delivery to tumors, thereby inhibiting tumor cell proliferation and offering an alternative administration approach for adoptive cell therapy in visceral solid tumors.