机构：[1]Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.[2]Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Parkville, Victoria, Australia.[3]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Dongcheng, Beijing, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Department of Oncology, University of Cambridge, Robinson Way, Cambridge, UK.[5]School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.[6]Research Centre for SHARP Vision, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.[7]Centre for Eye and Vision Research (CEVR), Hong Kong, China.[8]Department of Optometry &[9] Visions Sciences, The University of Melbourne, Melbourne, Parkville, Victoria, Australia.[9]Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.广东省人民医院[10]China-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, PR China.[11]Phase I Clinical Trial Research Ward, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, PR China.[12]Artificial Intelligence and Modelling in Epidemiology Program, Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia.[13]School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
To explore associations between optical coherence tomography (OCT) parameters and mortality risk.This study used data from the UK Biobank participants with eligible OCT data. Feature selection was conducted with the least absolute shrinkage and selection operator. Selected parameters were fitted into Cox regression, with the full model adjusting for demographic, socioeconomic, lifestyle, and genetic factors.During a median follow-up duration of 10.6 years, 3174 were deceased. After matching the deceased and surviving participants (1:3) by age and gender, 12,696 were included. Ten out of 18 parameters showed significant associations with all-cause mortality. Each standard deviation increase in optic disc diameter parameters (hazard ratios [HRs] ranging from 1.042 to 1.052), thinning of ganglion cell-inner plexiform layer (HR = 0.958, 0.920-0.998), thinning of the photoreceptor layer and its sublayers (HRs = 0.937-0.960) were significant biomarkers of all-cause mortality. Cause-specific analyses by mortality age revealed that thinner photoreceptor layer and sublayers were significantly associated with circulatory premature mortality (HRs = 0.856-0.915).Enlarging disc diameter, thinning of ganglion cell-inner plexiform layer, and thinning of photoreceptor layers are associated with all-cause mortality, with photoreceptor thinning especially linked to premature circulatory mortality.These findings suggest that specific OCT parameters could serve as noninvasive biomarkers for mortality risk assessment, potentially enhancing early identification of individuals at higher risk of premature death, particularly from circulatory diseases.
基金：
the National Key R&D Program
of China (022YFC2505100, 2022YFC2304900);
Outstanding Young Scholars Support Program
(3111500001); Xi’anJiaotong University Basic
Research and Profession Grant (xtr022019003,
xzy032020032) and Xi’an Jiaotong University Young
Scholar Support Grant (YX6J004).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|2 区医学
小类|2 区眼科学
最新[2025]版：
大类|2 区医学
小类|2 区眼科学
第一作者：
第一作者机构：[1]Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.[2]Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Parkville, Victoria, Australia.
通讯作者：
通讯机构：[1]Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.[2]Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Parkville, Victoria, Australia.[5]School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.[6]Research Centre for SHARP Vision, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.[7]Centre for Eye and Vision Research (CEVR), Hong Kong, China.[9] Visions Sciences, The University of Melbourne, Melbourne, Parkville, Victoria, Australia.[9]Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.[10]China-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, PR China.[11]Phase I Clinical Trial Research Ward, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, PR China.[12]Artificial Intelligence and Modelling in Epidemiology Program, Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia.[13]School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
推荐引用方式(GB/T 7714)：
Yusufu Mayinuer,Kang Mengtian,Dayimu Alimu,et al.Photoreceptor Layer Thinning as Biomarker for Circulatory Premature Mortality: UK Biobank Cohort Study[J].Translational Vision Science & Technology.2025,14(8):10.doi:10.1167/tvst.14.8.10.
APA：
Yusufu Mayinuer,Kang Mengtian,Dayimu Alimu,Shi Danli,Zhu Lisa Zhuoting...&Zhang Lei.(2025).Photoreceptor Layer Thinning as Biomarker for Circulatory Premature Mortality: UK Biobank Cohort Study.Translational Vision Science & Technology,14,(8)
MLA：
Yusufu Mayinuer,et al."Photoreceptor Layer Thinning as Biomarker for Circulatory Premature Mortality: UK Biobank Cohort Study".Translational Vision Science & Technology 14..8(2025):10
