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The Longitudinal Association Between Intrinsic Capacity and Functional Ability in Older Adults: Comparing Findings from the Cross-Lagged Panel Model and the Random-Intercept Cross-Lagged Panel Model

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机构: [1]Yilin Cheng, Msc, School of Nursing, Capital Medical University, Beijing, China. [2]Shuqin Xiao, PhD, Professor, School of Nursing, Capital Medical University, Beijing, China. [3]Yurun Cai, PhD, Professor, School of Nursing, University of Pittsburgh, Pittsburgh, America. [4]Liwei Jing, PhD, Professor, School of Nursing, Capital Medical University, Beijing, China. [5]Weiyao Li, Msc, School of Nursing, Capital Medical University, Beijing, China. [6]Xue Liu, Msc, Department of Nasal Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
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关键词: : Healthy aging Activities of daily living Geriatric nursing

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Intrinsic Capacity (IC) is a multidimensional construct defined by the World Health Organization (WHO). Although IC has been established as a significant predictor of functional decline in older adults, emerging evidence suggests that functional impairment may, in turn, accelerate the degradation of IC, indicating a potential bidirectional relationship. Therefore, this study aims to systematically examine the potential bidirectional relationship between IC and functional ability.This study analyzed longitudinal data from 2,233 adults aged 60 and above from the China Health and Retirement Longitudinal Study (CHARLS, 2011-2015). Cross-lagged panel models (CLPM) and random-intercept cross-lagged panel models (RI-CLPM) were used to examine bidirectional associations between IC and functional ability. IC (0-100) was assessed across five domains: locomotion, cognition, psychological well-being, vitality, and sensory function. Functional ability was measured using scores for basic (BADL: 0-18) and instrumental (IADL: 0-15) activities of daily living at three time points. Models were adjusted for sociodemographic, health, and behavioral factors.Compared to CLPM, RI-CLPM better captured the dynamic trajectory of functional status in older adults. IC decline significantly predicted BADL deterioration (β  =  0.089-0.109, p < 0.05), but BADL changes did not significantly affect IC. A bidirectional relationship existed between IC and IADL, with IC's effect on IADL (β  =  0.206-0.236, p < 0.001) being stronger than the reverse (β  =  0.093-0.100, p < 0.001).This study employed CLPM and RI-CLPM to investigate the dynamic relationship between IC and functional ability. These results offer new directions for developing interventions to promote healthy aging.© The Author(s) 2025. Published by Oxford University Press on behalf of the Gerontological Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

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大类 | 2 区 医学
小类 | 2 区 老年医学 2 区 老年医学(社科)
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 老年医学 2 区 老年医学(社科)
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第一作者机构: [1]Yilin Cheng, Msc, School of Nursing, Capital Medical University, Beijing, China.
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