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CALD1-derived circ-0003746 targeting miR-526b promotes EMT-mediated bladder cancer progression

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机构: [1]Tongji University School of Medicine, Shanghai, China [2]Department of Urology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China [3]Department of Urology, Zhongda Hospital, Southeast University, Nanjing, China [4]Department of Urology, Bengbu First People’s Hospital, Anhui, China [5]Department of Interventional Radiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China [6]Department of Urology, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China
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关键词: Bladder cancer CALD1 Circ-0003746 miR-526b EMT

摘要:
CALD1 is critical to bladder cancer (BCa) development. Circ-0003746 is a circRNA derived from two exons of CALD1. However, the functional role of circ-0003746 in BCa remains inadequately explored. This study investigated its involvement in BCa. Circ-0003746 was found to be overexpressed in BCa tissues and cell lines. Silencing circ-0003746 suppressed both proliferation and migration of BCa cells in vitro and in vivo. miR-526b was identified as a potential target of circ-0003746. Luciferase reporter assays confirmed the interaction between circ-0003746 and miR-526b. Mechanistically, circ-0003746 promotes epithelial-mesenchymal transition (EMT) by sequestering miR-526b, thereby advancing BCa progression. These findings highlight the role of circ-0003746 in regulating the miR-526b/EMT axis, positioning it as a potential biomarker for BCa.Copyright © 2025. Published by Elsevier Inc.

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出版当年[2025]版:
大类 | 3 区 生物学
小类 | 4 区 细胞生物学 4 区 肿瘤学
最新[2025]版:
大类 | 3 区 生物学
小类 | 4 区 细胞生物学 4 区 肿瘤学
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第一作者机构: [1]Tongji University School of Medicine, Shanghai, China [2]Department of Urology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
通讯作者:
通讯机构: [4]Department of Urology, Bengbu First People’s Hospital, Anhui, China [6]Department of Urology, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China
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