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Advances in the Study of Pyroptosis in Dermatological Disorders

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资源类型：
Pubmed体系：
作者：
Xue Shenghao[1] * ; Lin Yumeng[2] * ; Liu Lusheng[3] * ; Wang Ke[4] ; Guo Qian[5] ; Zhang Ruyi[1] ; Zeng Kaisheng[1] ; Jiang Jin[1] ; Deng Zhinan[1] ; Yuan Lan[1] ; Han Zhongyu[1] ; Zuo Xiaohong[6,7,8] ;
机构： [1]School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China. [2]Health Management Center, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China. [3]Department of Acupuncture and Moxibustion, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. [4]Deyang Hospital Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Deyang, China. [5]Department of Rhinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [6]School of Eye, Chengdu University of Traditional Chinese Medicine, Chengdu, China. [7]Ineye Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China. [8]Key Laboratory of Sichuan Province for Ophthalmopathy Prevention and Cure and Visual Function Protection with Traditional Chinese Medicine Laboratory, Chengdu, China.
出处：
DOI： 10.1111/exd.70148
ISSN：

关键词： chronic spontaneous urticaria psoriasis pyroptosis systemic lupus erythematosus systemic sclerosis vitiligoatopic dermatitis

摘要：
Pyroptosis is a proinflammatory procedural cell die-off characterised by the forming of membrane pores that are mediated by a series of aerogelin proteins. Pyroptosis occurs by caspase-1 dependent typical signalling pathways, caspase-4/5/11 dependent atypical signalling pathways, and other signalling pathways (GSDME, GSDMD, GSDMA, GSDMB and GSDMC mediated signalling pathways). Pyroptosis may assist in the elimination of the pathogen as a type of mechanism of host defence, but pyroptosis-induced inflammation can lead to dysfunction and organ damage, exacerbating the pathology of the disease. Several existing researches have suggested that pyroptosis is implicated in the etiopathogenesis of a majority of dermatologic disorders, including systemic lupus erythematosus (SLE), psoriasis (PA), atopic dermatitis (AD), systemic sclerosis (SSc), vitiligo and chronic spontaneous urticaria (CSU). In this review, we examine the available literature, focusing on the mechanistic aspects of pyroptosis and the involvement of pyroptosis in the six dermatologic disorders mentioned above, to aid in further research in the future.© 2025 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

基金：
the “Xinglin Scholar” Disciplinary Talent Research Promotion Program of Chengdu University of Traditional Chinese Medicine, the Seedling Talent Special Project (MPRC2023035), the Natural Science Foundation of Sichuan Province (2023NSFSC1801), and the Special Research Project on Traditional Chinese Medicine of the Administration of Traditional Chinese Medicine of Sichuan Province (2024MS041).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 3 区 医学
小类 | 2 区 皮肤病学
最新[2025]版：
大类 | 3 区 医学
小类 | 2 区 皮肤病学
第一作者：
第一作者机构： [1]School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
共同第一作者：
通讯作者：
通讯机构： [6]School of Eye, Chengdu University of Traditional Chinese Medicine, Chengdu, China. [7]Ineye Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China. [8]Key Laboratory of Sichuan Province for Ophthalmopathy Prevention and Cure and Visual Function Protection with Traditional Chinese Medicine Laboratory, Chengdu, China.
推荐引用方式(GB/T 7714)：
Xue Shenghao,Lin Yumeng,Liu Lusheng,et al.Advances in the Study of Pyroptosis in Dermatological Disorders[J].Experimental Dermatology.2025,34(8):e70148.doi:10.1111/exd.70148.
APA：
Xue Shenghao,Lin Yumeng,Liu Lusheng,Wang Ke,Guo Qian...&Zuo Xiaohong.(2025).Advances in the Study of Pyroptosis in Dermatological Disorders.Experimental Dermatology,34,(8)
MLA：
Xue Shenghao,et al."Advances in the Study of Pyroptosis in Dermatological Disorders".Experimental Dermatology 34..8(2025):e70148

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