Burns cause significant physical harm and complex psychological issues. The dual influence of physical and psychological factors can contribute to difficulties in rehabilitation of patients. Consequently, it is crucial to identify a treatment approach that simultaneously promotes mental health and functional recovery. Acceptance and Commitment Therapy (ACT) has garnered significant attention for its beneficial effects on both the physical and psychological wellbeing of individuals. This study aims to investigate the influence of integrating ACT with traditional burn rehabilitation methods on the psychological wellbeing and physical function of patients with burns during their recovery process.This study was a randomized controlled trial. Fifty-four patients with moderate to severe burns at the Burn Rehabilitation Center of Wuhan Third Hospital participated in the study from October 2022 to April 2024. They were randomly assigned to the ACT group and the Standard of Care (SOC) group. Patients in the SOC group began a conventional burn rehabilitation program, while those in the ACT group received ACT treatment alongside the traditional program. At the start of the trial and after 12 weeks, patients were assessed for anxiety, depression, sleep quality, activity of daily living (ADL), and upper and lower limb function, using the appropriate scales: Self-Rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS), the Assens Insomnia scale (AIS), the modified Barthel index, and the Fugl-Meyer motor function scale.Before the trial, no significant differences were found between the two groups in anxiety, depression, sleep quality, ADL, or motor function (P > 0.05). After 12 weeks, the scores of anxiety, depression, and sleep quality in the ACT group were better than those in the SOC group (P < 0.05). After 12 weeks, there were no significant differences between the two groups in Fugl-Meyer motor function scores or activities of daily living scores (P > 0.05), indicating that ACT combined with conventional rehabilitation improved mental health but had no additional benefits for physical function.Combining ACT with routine rehabilitation training in moderate to severe burn patients can improve their anxiety, depression, and sleep quality.Copyright © 2025. Published by Elsevier Ltd.