Purpose of ReviewAllergic rhinitis (AR) is a very common and troubling disorder that severely affects patients' quality of life. There is an urgent need to understand the immunopathologic factors behind the disease. Acetylcholine is a neurotransmitter that has emerged as one of the critical regulators of AR pathogenesis.Recent FindingsThe elevation of cholinergic transmitters and their muscarinic receptors is a major driver of nasal hypersensitivity and excessive nasal secretion in AR pathogenesis. In addition to inducing extensive mucus secretions, the relevant research data for acetylcholine in immune regulation and airway remodeling remain fragmented. The immunopathological mechanisms underlying acetylcholine signaling pathways associated with AR may provide clinical practitioners with novel insights for medication selection in controlling patients' symptoms.SummaryWe highlight the roles of acetylcholine in AR pathogenesis and the findings of clinical trials on intranasal anticholinergics use in AR, and hope to provide a reference for patients' management.
基金：
National key R&D program of China [2022YFC2504100]; Changjiang scholars and innovative research team [IRT13082]; Natural Science Foundation of China [82471132, 82071022]; Beijing Hospitals Authority Clinical Medicine Development of special [ZLRK202303]
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Allergy, 17 HouGouHuTong, Beijing 100730, Peoples R China[2]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, 1 DongJiaoMinXiang, Beijing 100730, Peoples R China[3]Beijing Inst Otolaryngol, Beijing Lab Allerg Dis, Beijing Key Lab Nasal Dis, Beijing 100005, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Allergy, 17 HouGouHuTong, Beijing 100730, Peoples R China[2]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, 1 DongJiaoMinXiang, Beijing 100730, Peoples R China[3]Beijing Inst Otolaryngol, Beijing Lab Allerg Dis, Beijing Key Lab Nasal Dis, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Li Xian,Zhang Yuan,Zhang Luo.The Roles of Acetylcholine and Muscarinic Receptors in Allergic Rhinitis: Mechanisms, Clinical Insights and Future Directions[J].CURRENT ALLERGY AND ASTHMA REPORTS.2025,25(1):doi:10.1007/s11882-025-01221-w.
APA：
Li, Xian,Zhang, Yuan&Zhang, Luo.(2025).The Roles of Acetylcholine and Muscarinic Receptors in Allergic Rhinitis: Mechanisms, Clinical Insights and Future Directions.CURRENT ALLERGY AND ASTHMA REPORTS,25,(1)
MLA：
Li, Xian,et al."The Roles of Acetylcholine and Muscarinic Receptors in Allergic Rhinitis: Mechanisms, Clinical Insights and Future Directions".CURRENT ALLERGY AND ASTHMA REPORTS 25..1(2025)
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