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Inter-tumor Heterogeneity of 68Ga-PSMA-11 Uptake in Metastatic Undifferentiated Sarcoma

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机构： [1]Department of Radiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine. [2]Departments of Nuclear Medicine, The First Affiliated Hospital of Naval Medical University. [3]Department of Pathology, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China. [4]Departments of Orthopedics, The First Affiliated Hospital of Naval Medical University.

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关键词： sarcoma undifferentiated sarcoma metastasis PSMA PET/CT

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Immunohistochemical studies show PSMA may be a potential target for molecular imaging and treatment in bone and soft tissue sarcomas. We describe 68Ga-PSMA-11 PET/CT findings in a case with metastatic undifferentiated sarcoma. The sarcoma lesions showed a high variability of 68Ga-PSMA-11 uptake measured by SUVmax, ranging from 3.2 to 21.5. This case indicates that undifferentiated sarcoma can show increased PSMA uptake, 68Ga-PSMA-11 PET may noninvasively evaluate the inter-tumor heterogeneity of PSMA expression, and PSMA-targeted radioligand therapy may be a promising therapeutic option for this aggressive sarcoma.Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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大类 | 3 区医学

小类 | 3 区核医学

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大类 | 3 区医学

小类 | 3 区核医学

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第一作者机构： [1]Department of Radiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine.

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