高级检索
当前位置: 首页 > 详情页

Visual outcomes associated with optical coherence tomography biomarkers in diabetic macular edema: A systematic review

文献详情

资源类型:
Pubmed体系:
机构: [1]McMaster University, Department of Surgery, Department of Surgery, Division of Ophthalmology, 2757 King Street East, Hamilton, Ontario, Canada [2]McMaster University, Department of Health Research Methods, Evidence and Impact, 1280 Main Street West, Hamilton, Ontario, Canada [3]Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada [4]Queen’s University, School of Medicine, Kingston, Ontario, Canada [5]McMaster University, Department of Anesthesia, 1280 Main Street West, Hamilton, Ontario, Canada [6]Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA [7]Augenarztpraxisgemeinschaft Gutblick AG, Pfaffikon, ¨ Switzerland [8]Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland [9]Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA [10]Doheny Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, USA [11]Retinal Disorders and Ophthalmic Genetics, Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA [12]Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia [13]Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Australia [14]NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital, London, UK [15]University of Sydney, Department of Ophthalmology, Australia [16]Centre for Innovation and Precision Eye Health, National University of Singapore, Singapore [17]Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore [18]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore [19]Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School Singapore, Singapore [20]The Retina Service of Wills Eye Hospital, Philadelphia, PA, USA [21]Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China [22]Retina Consultants of Texas, Houston, Texas, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA
出处:
ISSN:

关键词: Diabetic macular edema Systematic review OCT biomarkers Anti-VEGF Diabetic retinopathy Diabetes Personalized treatment Biomarkers

摘要:
We evaluated the value of baseline structural optical coherence tomography (OCT) biomarkers in determining functional treatment response at 6,12-, and 24-months following treatment initiation in patients undergoing anti-vascular endothelial growth factor, steroid, or laser treatment for diabetic macular edema (DME). Ovid MEDLINE, EMBASE, and Web of Science databases were searched from inception for studies evaluating the association between baseline OCT biomarkers and best-recorded central visual acuity (VA). A synthesis using vote counting based on the direction of effect in relation to a five-letter minimally important difference was used. GRADE guidelines informed the certainty of evidence. Ninety-six studies evaluating 29 biomarkers were included. No biomarker with at least 'Low' certainty was associated with improved VA. Greater baseline ellipsoid zone (EZ) disruption and hyperreflective foci were associated with decreased VA at 6 months with "Low" certainty of evidence. There was also "Low" certainty that increased baseline disorganization of the retinal inner layers, increased baseline disruption of the external limiting membrane or EZ were associated with decreased VA at 12 months. No biomarker was associated with a poor prognosis with at least 'Moderate' certainty. The certainty was downgraded due to inadequately controlling for confounders and a lack of standardization regarding how biomarkers were defined and outcomes were measured.Copyright © 2025. Published by Elsevier Inc.

语种:
PubmedID:
中科院(CAS)分区:
出版当年[2025]版
大类 | 2 区 医学
小类 | 2 区 眼科学
最新[2025]版
大类 | 2 区 医学
小类 | 2 区 眼科学
第一作者:
第一作者机构: [1]McMaster University, Department of Surgery, Department of Surgery, Division of Ophthalmology, 2757 King Street East, Hamilton, Ontario, Canada [2]McMaster University, Department of Health Research Methods, Evidence and Impact, 1280 Main Street West, Hamilton, Ontario, Canada
通讯作者:
通讯机构: [1]McMaster University, Department of Surgery, Department of Surgery, Division of Ophthalmology, 2757 King Street East, Hamilton, Ontario, Canada [2]McMaster University, Department of Health Research Methods, Evidence and Impact, 1280 Main Street West, Hamilton, Ontario, Canada
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:28971 今日访问量:0 总访问量:1619 更新日期:2025-10-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学附属北京同仁医院 技术支持:重庆聚合科技有限公司 地址:北京市东城区东交民巷1号(100730)