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Cellular-Level Assessment of Macular Development in Patients with FEVR Using Multimodal Imaging: A Prospective Cohort Study

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机构： [1]Shenzhen Eye Hospital, Jinan University, China. [2]Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, China. [3]Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [4]Advanced Ophthalmology Laboratory (AOL), Robotrak Technologies, Nanjing, China [5]Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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关键词： Familial exudative vitreoretinopathy Multimodal imaging Foveal avascular zone Adaptive optics Cone density Retinal thickness

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To investigate the multimodal characteristics of macula in patients with familial exudative vitreoretinopathy (FEVR) at a cellular level.Prospective cohort study.A total of 46 FEVR-affected and healthy eyes were enrolled from July to October 2024 and underwent multimodal examinations. Participants with conditions such as foveal hypoplasia (FH), a history of ocular surgery or trauma in both the control and FEVR groups were excluded.All participants were underwent examinations of scanning laser ophthalmoscopy (SLO), ultra-wide-field swept source optical coherence tomography angiography (UWF SS-OCTA), and adaptive optics (AO)-SLO to acquire metrics of multimodal macular characteristics such as macular appearance, layered structure, vasculature and photoreceptor distribution. The baseline information such as best-corrected visual acuity (BCVA), spherical equivalent (SE), and axial length (AL) were also measured.Comparing to age (9.76 years on average), gender (52% femal), SE (-1.01D on average) and AL (23.66mm on average)-matched healthy eyes, FEVR-affected eyes without FH had increased foveal avascular zone (FAZ) perimeter in deep capillary plexus (DCP), partly thickening inner retina layers and thinning outer nuclear layer, as well as partly lower vessel density of DCP (P<0.05). In cellular-level, eyes with FEVR showed numerically lower cone density and larger cone spacing in fovea, but significantly higher cone density (P=0.03) and smaller cone spacing (P=0.02) in parafovea, as well as higher cone dispersion and lower regularity (P<0.05). Foveal and parafoveal cone density in participants with low BCVA were numerically higher.Patients with FEVR without FH may be characterized by irregular FAZ morphology and cone distribution, exhibiting lower foveal and higher parafoveal cone densities, which was not correlated with their BCVA and may serve as clinical biomarkers for diagnostic assistance in FEVR. Participants with low BCVA but morphologically normal macular structure may harbor underlying cone abnormalities, underscoring the necessity for more thorough assessment, warranting greater caution in diagnosing amblyopia until excluding the influence of cellular-level abnormalities.Copyright © 2025. Published by Elsevier Inc.

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大类 | 1 区

医学

小类 | 1 区眼科学

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大类 | 1 区

医学

小类 | 1 区眼科学

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第一作者机构： [1]Shenzhen Eye Hospital, Jinan University, China.

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通讯机构： [1]Shenzhen Eye Hospital, Jinan University, China. [2]Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, China.

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