机构：[1]Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.[2]Singapore Eye Research Institute, Singapore, Singapore.[3]Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.[4]Department of Ophthalmology, Columbia University, New York, New York, United States.[5]Department of Ophthalmology, Emory School of Medicine, Atlanta, Georgia, United States.[6]SERI-NTU Advanced Ocular Engineering (STANCE), Singapore, Singapore.[7]School of Chemical and Biological Engineering, Nanyang Technological University, Singapore, Singapore.[8]Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Vienna, Austria.[9]Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria.[10]Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland.[11]Fondation Ophtalmologique Adolphe De Rothschild, Paris, France.[12]Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany.[13]L. V. Prasad Eye Institute, Hyderabad, Telangana, India.[14]Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China.[15]Legacy Health Research Institute, Portland, Oregon, United States.[16]Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Korea.[17]Singapore National Eye Center, Singapore, Singapore.
The purpose of this study was to investigate associations among intraocular pressure (IOP), axial length (AXL), and optic nerve head (ONH) characteristics in highly myopic eyes.This retrospective cross-sectional study included highly myopic eyes with a refractive error of ≤-6.0 diopters (D) or an AXL of ≥26 mm, without glaucomatous optic neuropathy. Using IOP profiles, obtained retrospectively over a 5-year period, we assessed maximum, median, and range of IOP readings. We performed cross-sectional measurements of morphometric ONH parameters on fundus photographs and optical coherence tomographic (OCT) images.The study included 201 eyes (134 individuals) with a mean AXL of 27.6 ± 1.4 mm and a mean maximum IOP of 16.6 ± 3.7 millimeters of mercury (mm Hg; median = 14.9 ± 2.5 mm Hg, range = 3.14 ± 3.13 mm Hg obtained in 5.25 ± 2.76 measurements). Longer AXL was associated (multivariable analysis) with higher disc ovality (β = 0.05, P < 0.001), longer disc-fovea distance (β = 0.22, P < 0.001), shallower lamina cribrosa depth (β = -20.5, P = 0.02), and thicker ganglion cell layer and retinal nerve fiber layer in the temporal/inferotemporal sectors (all P < 0.05) with adjustments for age and gender. Higher mean maximum IOP readings were linked to deeper lamina cribrosa depth (β = 6.03, P = 0.006) and reduced disc rotation angle (β = -0.31, P = 0.04); higher mean median IOP was associated with smaller Bruch's membrane opening area (β = -0.06, P = 0.02). AXL was inversely associated with mean median IOP (β = -0.19, P = 0.02).Higher IOP and longer AXL are associated with distinct structural changes of the ONH in highly myopic eyes, particularly involving the lamina cribrosa. Elevated IOP but not AXL was associated with ONH features characteristic of glaucoma.
基金：
the Singapore Ministry of Health’s National Medical Research Council under the Transition Award (MOH-000625-
00) and Clinician Scientist Award (MOH-CSAINV24jan-0003)
schemes.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|2 区医学
小类|2 区眼科学
最新[2025]版：
大类|2 区医学
小类|2 区眼科学
第一作者：
第一作者机构：[1]Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
通讯作者：
通讯机构：[2]Singapore Eye Research Institute, Singapore, Singapore.[3]Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.[17]Singapore National Eye Center, Singapore, Singapore.
推荐引用方式(GB/T 7714)：
Wong Maverick Wenhao,Chong Crystal,Sharma Swati,et al.Independent Effects of Axial Length and Intraocular Pressure on the Highly Myopic Optic Nerve Head[J].Investigative Ophthalmology & Visual Science.2025,66(12):49.doi:10.1167/iovs.66.12.49.
APA：
Wong Maverick Wenhao,Chong Crystal,Sharma Swati,Phang Lee Ching,Lor Samantha...&Chong Rachel S.(2025).Independent Effects of Axial Length and Intraocular Pressure on the Highly Myopic Optic Nerve Head.Investigative Ophthalmology & Visual Science,66,(12)
MLA：
Wong Maverick Wenhao,et al."Independent Effects of Axial Length and Intraocular Pressure on the Highly Myopic Optic Nerve Head".Investigative Ophthalmology & Visual Science 66..12(2025):49
