机构：[1]Institute and Department of Endocrinology and Metabolism, ShanghaiNinth People’s Hospital Affiliated to Shanghai Jiao Tong University School ofMedicine, Shanghai, China[2]Department of Endocrinology, ShanghaiTongren Hospital, Affiliated to Shanghai Jiao Tong University School ofMedicine, Shanghai, China
Background Primary hyperparathyroidism is characterized by hypercalcemia and elevated or inappropriately normal serum levels of parathyroid hormone. Brown tumor of bone is a rare non-neoplastic lesion resulted from abnormal bone metabolism in hyperparathyroidism. However, nowadays, skeletal disease caused by primary hyperparathyroidism is uncommon. We report a case of brown tumor in the mandible as the initial exhibition of primary hyperparathyroidism associated with an atypical parathyroid adenoma. Case presentation The patient was a 49-year-old female, she had a pain mass on the right mandible a year ago and was treated with root canal therapy and marginal resection. After seven months, the mass recurred and enlarged. Enhanced CT scan, laboratory examination, Ultrasonography, Tc-99m-MIBI SPECT-CT scintiscan and pathological examination were used to confirm the diagnosis of brown tumor. The patient's symptom improved after parathyroidectomy. Conclusions Tc-99m-MIBI SPECT/CT scintigraphy is a highly sensitive examination of the localization diagnosis of hyperparathyroidism. Brown tumors should be considered in the differential diagnosis of osteolytic lesions to avoid unnecessary and harmful interventions.
基金：
National Natural Science Foundation of China (NSFC) [:81670717]
第一作者机构：[1]Institute and Department of Endocrinology and Metabolism, ShanghaiNinth People’s Hospital Affiliated to Shanghai Jiao Tong University School ofMedicine, Shanghai, China[2]Department of Endocrinology, ShanghaiTongren Hospital, Affiliated to Shanghai Jiao Tong University School ofMedicine, Shanghai, China
通讯作者：
推荐引用方式(GB/T 7714)：
Xu Bojin,Yu Jie,Lu Yingli,et al.Primary hyperparathyroidism presenting as a brown tumor in the mandible: a case report[J].BMC ENDOCRINE DISORDERS.2020,20(1):doi:10.1186/s12902-019-0480-2.
APA：
Xu, Bojin,Yu, Jie,Lu, Yingli&Han, Bing.(2020).Primary hyperparathyroidism presenting as a brown tumor in the mandible: a case report.BMC ENDOCRINE DISORDERS,20,(1)
MLA：
Xu, Bojin,et al."Primary hyperparathyroidism presenting as a brown tumor in the mandible: a case report".BMC ENDOCRINE DISORDERS 20..1(2020)
