Isolation rearing (IR) enhances aggressive behavior, and the central serotonin (5-hydroxytryptamine, 5-HT) system has been linked to IR-induced aggression. However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2(-/-) and Lmx1b(-/-), we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1b(-/-) mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1b(-/-) mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1b(-/-) mice. Our results link the serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81425009, 31630028, 91632305, 30950030, 31170988, 81671044]; National Basic Research Development Program (973 Program) of ChinaNational Basic Research Program of China [2009CB522002]
第一作者机构：[1]Peking Univ, Coll Life Sci, State Key Lab Membrane Biol, Beijing 100871, Peoples R China[8]PKU IDG McGovem Inst Brain Res, Beijing 100871, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Peking Univ, Coll Life Sci, State Key Lab Membrane Biol, Beijing 100871, Peoples R China[4]Peking Univ, Sch Psychol & Cognit Sci, Beijing Key Lab Behav & Mental Hlth, Beijing 100871, Peoples R China[5]Beijing Inst Brain Disorders, Beijing 100069, Peoples R China[8]PKU IDG McGovem Inst Brain Res, Beijing 100871, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Yiqiong,Sun Yunong,Zhao Xiaoyan,et al.Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin[J].NEUROSCIENCE BULLETIN.2019,35(5):841-852.doi:10.1007/s12264-019-00373-w.
APA：
Liu, Yiqiong,Sun, Yunong,Zhao, Xiaoyan,Kim, Ji-Young,Luo, Lu...&Zhang, Yan.(2019).Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin.NEUROSCIENCE BULLETIN,35,(5)
MLA：
Liu, Yiqiong,et al."Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin".NEUROSCIENCE BULLETIN 35..5(2019):841-852
