A group of proteins, small ubiquitin-like modifier (SUMO) proteins, has been shown to play a major role in rodent cerebral ischemia. Here, we proved that transient global cerebral ischemia induces a marked increase in protein sumo2/3 conjugation levels, we also find that global sumo2/3 conjugation is involved in ischemic tolerance in mice. Mice preconditioned by sublethal ischemia were less vulnerable to severe ischemia than non-preconditioned mice. Five-minute BCCAO precondition decreased the levels of SUMO2/3-conjugated proteins induced by MCAO. These findings suggest that maintenance of a globally decreased SUMO2/3 (and maybe SUMO-2/3) conjugation level as revealed by immunoblot assays is a component of ischemic tolerance.
基金：
doctoral research startup fund of Tong Ren Hospital Shanghai Jiaotong University School of Medicine
第一作者机构：[1]Shanghai Jiao Tong Univ, Tong Ren Hosp, Sch Med, Dept Neurol, Shanghai Xianxia Rd 1111, Shanghai 200336, Peoples R China[*1]Department of Neurology ,Tong Ren Hospital Shanghai Jiaotong University School of Medicine, Shanghai Xianxia Road No.1111, China.
共同第一作者：
通讯作者：
通讯机构：[1]Shanghai Jiao Tong Univ, Tong Ren Hosp, Sch Med, Dept Neurol, Shanghai Xianxia Rd 1111, Shanghai 200336, Peoples R China[*1]Department of Neurology ,Tong Ren Hospital Shanghai Jiaotong University School of Medicine, Shanghai Xianxia Road No.1111, China.
推荐引用方式(GB/T 7714)：
Zhang Huijun,Huang Dehua,Zhou Jie,et al.SUMOylation participates in induction of ischemic tolerance in mice[J].BRAIN RESEARCH BULLETIN.2019,147:159-164.doi:10.1016/j.brainresbull.2019.02.012.
APA：
Zhang, Huijun,Huang, Dehua,Zhou, Jie,Yue, Yunhua&Wang, Xiaoping.(2019).SUMOylation participates in induction of ischemic tolerance in mice.BRAIN RESEARCH BULLETIN,147,
MLA：
Zhang, Huijun,et al."SUMOylation participates in induction of ischemic tolerance in mice".BRAIN RESEARCH BULLETIN 147.(2019):159-164
