机构：[1]Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China[2]Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai Institute of Liver Diseases, Shanghai 200032, China[3]Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, School of Clinical Medicine of Nanjing Medical University, Shanghai 200072, China[4]Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200336, China[5]Department of Oncology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China[6]Department of Gastroenterology, Jinshan Hospital of Fudan University, Jinshan, Shanghai 201508, China[7]Department of Gastroenterology, Shanghai Tenth People's Hospital Chongming Branch, Tongji University School of Medicine, Shanghai 202157, China
Isorhamnetin, a flavonoid compound extracted from plants' fruit or leaves, like sea buckthorn (Hippophae rhamnoides L.), has many biological functions, including anti-tumor, anti-oxidant and anti-inflammatory effect. The present study is in order to explore the hepatoprotective effect of isorhamnetin on concanavalin A (ConA)-induced acute fulminant hepatitis and the underlying mechanism. Mice were injected with ConA (25 mg/kg) to induce acute fulminant hepatitis, three doses of isorhamnetin (10/30/90 mg/kg) was intraperitoneally administrated about 1 h previously. The serum and liver tissues were harvested at 2, 8, and 24 h after ConA injection. The levels of serum liver enzymes and proinflammatory cytokines were significantly reduced in isorhamnetin administration groups. Besides, isorhamnetin improved pathological damage. Furthermore, iso-rhamnetin affected P38/PPAR-alpha pathway, and subsequently regulated the expression of apoptosis and autophagy related proteins. The present study investigated that isorhamnetin inhibits apoptosis and autophagy via P38/PPAR-alpha pathway in mice.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670472, 81700502, 81500466]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区药学4 区医学：研究与实验
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2016]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2PHARMACOLOGY & PHARMACY
最新[2024]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
通讯作者：
推荐引用方式(GB/T 7714)：
Lu Xiya,Liu Tong,Chen Kan,et al.Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-alpha pathway in mice[J].BIOMEDICINE & PHARMACOTHERAPY.2018,103:800-811.doi:10.1016/j.biopha.2018.04.016.
APA：
Lu, Xiya,Liu, Tong,Chen, Kan,Xia, Yujing,Dai, Weiqi...&Guo, Chuanyong.(2018).Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-alpha pathway in mice.BIOMEDICINE & PHARMACOTHERAPY,103,
MLA：
Lu, Xiya,et al."Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-alpha pathway in mice".BIOMEDICINE & PHARMACOTHERAPY 103.(2018):800-811
