机构：[1]Division of Dentistry, Beijing Tongren Hospital, Capital Medical University, Beijing, China临床科室口腔科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China[3]Biomaterials & Tissue Engineering Division, Department of Endodontics, Periodontics and Prosthodontics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA[4]Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA[5]Department of Mechanical Engineering, University of Maryland, Baltimore County, MD 21250, USA
Orthodontic treatments increase the incidence of white spot lesions. The objectives of this study were to develop an antibacterial orthodontic cement to inhibit demineralization, and to evaluate its enamel shear bond strength and anti-biofilm properties. Novel antibacterial monomer dimethylaminohexadecyl methacrylate (DMAHDM) was synthesized and incorporated into Transbond XT at 0, 1.5 and 3% by mass. Anti-biofilm activity was assessed using a human dental plaque microcosm biofilm model. Shear bond strength and adhesive remnant index were also tested. Biofilm activity precipitously dropped when contacting orthodontic cement with DMAHDM. Orthodontic cement containing 3% DMAHDM significantly reduced biofilm metabolic activity and lactic acid production (p<0.05), and decreased biofilm colony-forming unit (CFU) by two log. Water-aging for 90 days had no adverse influence on enamel shear bond strength (p>0.1). By incorporating DMAHDM into Transbond XT for the first time, the modified orthodontic cement obtained a strong antibacterial capability without compromising the enamel bond strength.
基金：
National Natural Science
Foundation of China [81400540 to KZ]; Beijing
Municipal Administration of Hospitals’ Youth Program
[QML20151401 to KZ]; Capital Medical University
Basic-Clinical Research Cooperation Fund [14JL78 to
KZ]; Beijing Municipal Administration of Hospitals’
Ascent Plan [DFL20151401 to YB]; National Institutes
of Health [R01 DE17974 to HX], and a Seed Grant (HX)
from the University of Maryland School of Dentistry.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|4 区医学
小类|4 区牙科与口腔外科4 区材料科学：生物材料
最新[2025]版：
大类|4 区医学
小类|4 区牙科与口腔外科4 区材料科学：生物材料
JCR分区：
出版当年[2015]版：
Q3DENTISTRY, ORAL SURGERY & MEDICINEQ4MATERIALS SCIENCE, BIOMATERIALS
最新[2024]版：
Q2DENTISTRY, ORAL SURGERY & MEDICINEQ4MATERIALS SCIENCE, BIOMATERIALS
第一作者机构：[1]Division of Dentistry, Beijing Tongren Hospital, Capital Medical University, Beijing, China[2]Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China
通讯作者：
推荐引用方式(GB/T 7714)：
Feng Xiaodong,Zhang Ning,Xu Hockin H. K.,et al.Novel orthodontic cement containing dimethylaminohexadecyl methacrylate with strong antibacterial capability[J].DENTAL MATERIALS JOURNAL.2017,36(5):669-676.doi:10.4012/dmj.2016-370.
APA：
Feng, Xiaodong,Zhang, Ning,Xu, Hockin H. K.,Weir, Michael D.,Melo, Mary Anne S....&Zhang, Ke.(2017).Novel orthodontic cement containing dimethylaminohexadecyl methacrylate with strong antibacterial capability.DENTAL MATERIALS JOURNAL,36,(5)
