Pancreatic cancer is a devastating disease with proclivity for early metastasis, which accounts for its poor prognosis. The clinical problem of pancreatic cancer is its resistance to conventional therapies, such as chemotherapy or radiation. Based upon these challenges, the focus of research on pancreatic cancer has shifted gradually towards the tumor microenvironment. The cancer microenvironment consists of various components, including fibroblasts, endothelial cells, immune cells, and endocrine cells, that interact with each other, and with the cancer cells in a complex fashion. Evidence is accumulating that the cancer microenvironment plays an active role in disease progression, and efforts are being made to target this interplay between cancer cells and host cells, to improve the prognosis of the disease. In the present review, we describe the cellular microenvironment of pancreatic ductal adenocarcinoma (PDA), the major type of pancreatic cancer. Our hope is that a better understanding of the cellular microenvironment of PDA will eventually lead to better treatments for this disease.
第一作者机构：[1]Shanghai Jiao Tong Univ, TongRen Hosp, Intervent Ctr, Sch Med, 786 Yuyuan Rd, Shanghai 200050, Peoples R China
通讯作者：
通讯机构：[1]Shanghai Jiao Tong Univ, TongRen Hosp, Intervent Ctr, Sch Med, 786 Yuyuan Rd, Shanghai 200050, Peoples R China[*1]Jiaotong Univ, Sch Med, St Lukes Hosp, Intervent Ctr, 786 Yuyuan Rd, Shanghai 200050, Peoples R China
推荐引用方式(GB/T 7714)：
Sun Xian-Jun,Jiang Ting-Hui,Zhang Xiao-Ping,et al.Role of the tumor microenvironment in pancreatic adenocarcinoma[J].FRONTIERS IN BIOSCIENCE-LANDMARK.2016,21:31-41.doi:10.2741/4374.
APA：
Sun, Xian-Jun,Jiang, Ting-Hui,Zhang, Xiao-Ping&Mao, Ai-Wu.(2016).Role of the tumor microenvironment in pancreatic adenocarcinoma.FRONTIERS IN BIOSCIENCE-LANDMARK,21,
MLA：
Sun, Xian-Jun,et al."Role of the tumor microenvironment in pancreatic adenocarcinoma".FRONTIERS IN BIOSCIENCE-LANDMARK 21.(2016):31-41
