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Tc-99m-3P-RGD2 molecular imaging targeting integrin alpha (v) beta (3) in head and neck squamous cancer xenograft

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Nuclear Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [2]Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China [3]Cardiovascular Institute & Fu Wai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100037, China [4]State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, China

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关键词： Head and neck squamous cell carcinoma Integrin alpha(v)beta(3) Molecular imaging Tc-99m-3P-RGD2 Angiogenesis

摘要：

Tc-99m-3P-RGD2 and SPECT/CT were valuable tools for selecting patient likely benefit from integrin alpha (v) beta (3) blocking therapy. To evaluate the feasibility of Tc-99m-3P-RGD2 imaging to detect head and neck squamous cell carcinoma, Tc-99m-3P-RGD2 was prepared and the relationship between its accumulation and integrin alpha (v) beta (3) expression in nude mice bearing HEP-2 or CNE-1 carcinoma xenograft were analyzed. This study demonstrated that Tc-99m-3P-RGD2, with high affinity to integrin alpha (v) beta (3), will provide basis for alpha (v) beta (3) involved individual therapy.

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出版当年[2014]版：

大类 | 4 区化学

小类 | 2 区核科学技术 4 区分析化学 4 区无机化学与核化学

最新[2025]版：

大类 | 3 区化学

小类 | 3 区无机化学与核化学 4 区分析化学 4 区核科学技术

JCR分区：

出版当年[2013]版：

Q1 NUCLEAR SCIENCE & TECHNOLOGY Q3 CHEMISTRY, ANALYTICAL Q3 CHEMISTRY, INORGANIC & NUCLEAR

最新[2024]版：

Q3 CHEMISTRY, INORGANIC & NUCLEAR Q3 NUCLEAR SCIENCE & TECHNOLOGY Q4 CHEMISTRY, ANALYTICAL

影响因子： 1.6 最新[2024版] 1.6 最新五年平均 1.415 出版当年[2013版] 1.242 出版当年五年平均 1.467 出版前一年[2012版] 1.034 出版后一年[2014版]

第一作者：

第一作者机构： [1]Department of Nuclear Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

通讯作者：

通讯机构： [2]Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China

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