Purpose: To examine a potential association between longitudinal changes in intraocular pressure (IOP), arterial blood pressure and body mass index (BMI) in a population-based setting. Methods: The longitudinal population-based Beijing Eye Study included 2355 subjects with an age of 45+ years who were examined in 2006 and in 2011. The participants underwent a detailed ophthalmic examination including tonometry and measurement of arterial blood pressure and BMI. Results: Data on IOP, arterial blood pressure and BMI measured in 2006 and in 2011 were available for 2257 (95.8%) subjects with a mean age of 59.5 +/- 9.7 years. The mean change in IOP was -1.25 +/- 2.26 mm Hg, mean change in mean blood pressure -7.4 +/- 12.1 mmHg, and mean change in BMI was 0.01 +/- 2.04 kg/m(2). In multivariate analysis, the 5-year change in IOP was significantly associated with a higher change in mean blood pressure (P<0.001; standardized regression coefficient Beta: 0.11; regression coefficient B:0.02; 95% confidence interval (CI): 0.01,0.03) after adjusting for younger age (P<0.001; Beta: -0.18; B: -0.04; 95% CI: -0.05,-0.03), shorter body stature (P = 0.002; Beta: -0.06; B: -0.06; 95% CI: -0.03,-0.01), thicker central corneal thickness (P<0.001; Beta: 0.19; B: 0.02; 95% CI: 0.01,0.02), deeper anterior chamber depth (P = 0.01; Beta: 0.05; B: 0.33; 95% CI: 0.07,0.60), and lower intraocular pressure at baseline (P<0.001; Beta: -0.56; B: -0.42; 95% CI: -0.45,-0.39). If the analysis included only longitudinal parameters, the change in IOP was significantly associated with a higher change in mean arterial blood pressure (P<0.001; Beta: 0.10; B: 0.02; 95% CI: 0.01,0.03) and a higher change in body mass index (P<0.04; Beta:0.04; B: 0.04; 95% CI: 0.01,0.09). Conclusions: In the 5-year follow-up of our population-based sample, a change in IOP was associated with a corresponding change in arterial blood pressure and with a corresponding change in body mass index. These longitudinal data support the notion of a physiological relationship between arterial blood pressure, intraocular pressure and body mass index. These findings may be of interest for the discussion of the pathogenesis of glaucomatous optic neuropathy.
基金：
This work was supported by the National Natural Science Foundation of China 81770890; Beijing NOVA Program 2011058.
第一作者机构：[1]Capital Univ Med Sci, Beijing Tongren Hosp, Beijing Inst Ophthalmol, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Univ Med Sci, Beijing Tongren Hosp, Beijing Inst Ophthalmol, Beijing, Peoples R China[2]Heidelberg Univ, Fac Clin Med Mannheim, Dept Ophthalmol, Mannheim, Germany
推荐引用方式(GB/T 7714)：
Wang Ya Xing,Xu Liang,Zhang Xiao Hui,et al.Five-Year Change in Intraocular Pressure Associated with Changes in Arterial Blood Pressure and Body Mass Index. The Beijing Eye Study[J].PLOS ONE.2013,8(10):doi:10.1371/journal.pone.0077180.
APA：
Wang, Ya Xing,Xu, Liang,Zhang, Xiao Hui,You, Qi Sheng,Zhao, Liang&Jonas, Jost B..(2013).Five-Year Change in Intraocular Pressure Associated with Changes in Arterial Blood Pressure and Body Mass Index. The Beijing Eye Study.PLOS ONE,8,(10)
MLA：
Wang, Ya Xing,et al."Five-Year Change in Intraocular Pressure Associated with Changes in Arterial Blood Pressure and Body Mass Index. The Beijing Eye Study".PLOS ONE 8..10(2013)
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