机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Ophthalmology, Tengzhou Central People’s Hospital, Tengzhou, Shandong Province, China[3]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China[4]Zaozhuang Municipal Hospital, Zaozhuang, Shandong Province, China
PURPOSE. To investigate the therapeutic impact of perceptual learning on juvenile amblyopia that is no longer responsive to patching treatment (PT group) or was never patch treated (NPT group). METHODS. Ten PT and 13 NPT subjects aged 8 to 17 years were trained with a grating acuity task for 40 to 60 sessions. Half in each group were further trained with single or crowded tumbling E acuity tasks for 8 to 10 sessions. RESULTS. Training improved grating acuity by -2.1% in the PT eyes and 36.1% in the NPT eyes, along with a boost of single and crowded E acuities by 0.9 or 0.7 lines in the PT eyes and 1.5 and 1.2 lines in the NPT eyes, in contrast to a nearly 5-line improvement in the same PT eyes after previous patching treatment. Stereoacuity was improved in some PT and NPT eyes. The single and crowded E acuity improvements were not significantly dependent on the pretraining acuity. The single and crowded E acuity and stereoacuity improvements were uncorrelated with grating acuity improvement, suggesting some random training impacts on different tasks and individuals. Further direct single and crowded E acuity training generated an additional 0.2- and 0.2-line boost for PT eyes and a 0.4- and 0.5-line boost for NPT eyes, resulting in overall single and crowded E acuity gains of 1.4 and 1.0 lines for PT eyes and 2.2 and 1.8 lines for NPT eyes. CONCLUSIONS. Perceptual learning has a small but significant therapeutic impact on both PT and NPT juvenile eyes, which is most likely to have clinical values for eyes with mild amblyopia. Early diagnosis and treatment are most important and effective. (Invest Ophthalmol Vis Sci. 2011;52:1531-1538) DOI:10.1167/iovs.10-6355
基金：
National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30725018]; Chang-Jiang Scholar Professorship
第一作者机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China[2]Department of Ophthalmology, Tengzhou Central People’s Hospital, Tengzhou, Shandong Province, China
共同第一作者：
通讯作者：
通讯机构：[3]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China[*1]Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, 19 Xinjiekouwaidajie, Beijing 100875, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Xiang-Yun,Zhang Ting,Jia Yan-Lei,et al.The Therapeutic Impact of Perceptual Learning on Juvenile Amblyopia with or without Previous Patching Treatment[J].INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2011,52(3):1531-1538.doi:10.1167/iovs.10-6355.
APA：
Liu, Xiang-Yun,Zhang, Ting,Jia, Yan-Lei,Wang, Ning-Li&Yu, Cong.(2011).The Therapeutic Impact of Perceptual Learning on Juvenile Amblyopia with or without Previous Patching Treatment.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,52,(3)
MLA：
Liu, Xiang-Yun,et al."The Therapeutic Impact of Perceptual Learning on Juvenile Amblyopia with or without Previous Patching Treatment".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 52..3(2011):1531-1538
医学