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p14(ARF) Genetic Polymorphisms and Susceptibility to Second Primary Malignancy in Patients With Index Squamous Cell Carcinoma of the Head and Neck

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作者：
Zhang, Yang[1,2] * ; Sturgis, Erich M.[1,3] ; Zafereo, Mark E.[1] ; Wei, Qingyi[3] ; Li, Guojun[1,3,*1] ;
机构： [1]Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas [2]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otolaryngology, Beijing, China [3]Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
出处：
DOI： 10.1002/cncr.25605
ISSN：

关键词： p14ARF squamous cell carcinoma of head and neck second primary malignancy genetic susceptibility polymorphism

摘要：
BACKGROUND: p14(ARF), an alternate reading frame (ARF) product of the cyclin-dependent kinase inhibitor 2A locus, plays a critical role in crosstalk between the tumor protein 53 (p53) and retinoblastoma (Rb) pathways and in cellular anticancer mechanisms. Therefore, the authors of this report investigated the association between single nucleotide polymorphisms (SNPs) of the p74(ARF) gene and the risk of developing a second primary malignancy (SPM) after an index squamous cell carcinoma of the head and neck (SCCHN). METHODS: The log-rank test and Cox proportional hazards models were used to assess the association of 2 p14(ARF) SNPs (reference SNP [rs]3731217 and rs3088440) with SPM-free survival and with the risk of developing an SPM among 1287 patients who had SCCHN. RESULTS: Patients with either p14(ARF) variant genotypes of the 2 polymorphisms had a significantly reduced SPM-free survival compared with patients with no variant genotypes (log-rank test; P = .006). Compared with the p14(ARF) thymine-thymine (TT) and guanine-guanine (GG) genotypes, the variant genotypes of p14(ARF) TG/GG and guanine-adenine (GA)/AA were associated with a significantly moderately increased risk of developing an SPM (p14(ARF) rs3731217: adjusted hazard ratio [aHR], 1.48; 95% confidence interval [CI], 1.00-2.19; p14(ARF) rs3088440: aHR, 1.61; 95% CI, 1.07-2.43). Moreover, after combining the variant genotypes of the 2 SNPs, patients who had variant genotypes were at significantly greater risk of developing an SPM compared with patients who had no variant genotypes (aHR, 3.07; 95% Cl, 1.54-6.12), and the risk was particularly pronounced in several subgroups. CONCLUSIONS: The current results suggested that there is a modestly increased risk of developing an SPM after an index SCCHN with each p14(ARF) polymorphism, and there is an even greater risk of developing an SPM for patients with combined variant genotypes of the 2 SNPs. Therefore, p14(ARF) polymorphisms may be susceptible markers of the risk of developing an SPM in patients with SCCHN. Cancer 2011;117:1227-35. (C) 2070 American Cancer Society.

基金：
American Laryngological, Rhinological, and Otological Society; University of Texas M. D. Anderson Cancer Center; National Institute of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 ES11740, CA131274, P-30 CA16672, CA135679, CA133099]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P30CA016672, K07CA133099, R03CA135679, R01CA131274] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [R01ES011740, R01ES015587] Funding Source: NIH RePORTER
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外文
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中科院(CAS)分区：
出版当年[2010]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学
最新[2025]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
JCR分区：
出版当年[2009]版：
Q1 ONCOLOGY
最新[2024]版：
Q1 ONCOLOGY

影响因子： 最新[2024版] 最新五年平均 出版当年[2009版] 出版当年五年平均 出版前一年[2008版] 出版后一年[2010版]

第一作者：
第一作者机构： [1]Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas [2]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otolaryngology, Beijing, China
通讯作者：
通讯机构： [1]Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas [3]Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas [*1]Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Unit 1445, 1515 Holcombe Blvd, Houston, TX 77030 USA
推荐引用方式(GB/T 7714)：
Zhang Yang,Sturgis Erich M.,Zafereo Mark E.,et al.p14(ARF) Genetic Polymorphisms and Susceptibility to Second Primary Malignancy in Patients With Index Squamous Cell Carcinoma of the Head and Neck[J].CANCER.2011,117(6):1227-1235.doi:10.1002/cncr.25605.
APA：
Zhang, Yang,Sturgis, Erich M.,Zafereo, Mark E.,Wei, Qingyi&Li, Guojun.(2011).p14(ARF) Genetic Polymorphisms and Susceptibility to Second Primary Malignancy in Patients With Index Squamous Cell Carcinoma of the Head and Neck.CANCER,117,(6)
MLA：
Zhang, Yang,et al."p14(ARF) Genetic Polymorphisms and Susceptibility to Second Primary Malignancy in Patients With Index Squamous Cell Carcinoma of the Head and Neck".CANCER 117..6(2011):1227-1235

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