机构：[1]Zhongshan Ophthalmic Center, Sun Yat-sen University, International Uveitis Study Laboratory, Uveitis Study Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangzhou 510060, Guangdong Province, China[2]Beijing Tongren Eye Center, Affiliate of Capital University of Medical Sciences, Beijing 100730, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院
AIM: To investigate the expression and the possible implication of CD40/CD40L costimulatory molecules in erythema nodosum of patients with Behcet's disease. METHODS: Sampling was done from erythema nodosum of 5 patients with Behcets disease and normal skin of 2 healthy individuals. Immunohistochemical staining was performed to examine the expression of CD4, CD8, CD19, CD68, HLA-DR, CD40 and CD40L molecules in the obtained tissues. RESULTS: Approximately 90% of epidermic cells in erythema nodosum expressed CD40 molecule. In the dermis and subcutaneous tissue, a significantly increased number of CD4(+)Tcells, CD8(+)Tcells, CD19(+)cells, CD68(+)cells, HLA-DR(+)cells, CD40L(+)cells, and CD40(+)cells were observed in the erythema nodosum as compared with that in normal skin. Double staining showed that CD40L molecules were expressed on 45% of CD4(+) T cells. CD40 molecules were expressed on 100% CD68(+) cells and 59.2% of HLA-DR+cells respectively. CONCLUSION: A number of CD40/CD40L costimulatory molecules are upregulated in the erythema nodosum of patients with Behcet's disease.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30400490]; Beijing Natural Science Foundation of ChinaBeijing Natural Science Foundation [7052023]; Foundation of Bureau of Guangdong Traditional Chinese Medicine, China [1050171]
第一作者机构：[1]Zhongshan Ophthalmic Center, Sun Yat-sen University, International Uveitis Study Laboratory, Uveitis Study Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangzhou 510060, Guangdong Province, China[2]Beijing Tongren Eye Center, Affiliate of Capital University of Medical Sciences, Beijing 100730, China
通讯作者：
通讯机构：[1]Zhongshan Ophthalmic Center, Sun Yat-sen University, International Uveitis Study Laboratory, Uveitis Study Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangzhou 510060, Guangdong Province, China[*1]Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 S Xianlie Road, Guangzhou 510060, China
推荐引用方式(GB/T 7714)：
Wang Hong,Yang Pei-Zeng,Peng Xiao-Yan,et al.An increased expression of CD40/CD40L costimulatory molecules in erythema nodosum of patients with Behcet's disease[J].INTERNATIONAL JOURNAL OF OPHTHALMOLOGY.2009,2(1):12-15.
APA：
Wang, Hong,Yang, Pei-Zeng,Peng, Xiao-Yan,Zhao, Meng,Zhou, Hong-Yan&Huang, Xiang-Kun.(2009).An increased expression of CD40/CD40L costimulatory molecules in erythema nodosum of patients with Behcet's disease.INTERNATIONAL JOURNAL OF OPHTHALMOLOGY,2,(1)
MLA：
Wang, Hong,et al."An increased expression of CD40/CD40L costimulatory molecules in erythema nodosum of patients with Behcet's disease".INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 2..1(2009):12-15
