OBJECTIVE: Using anterior segment optical coherence tomography (AS-OCT), we investigated the epithelial thickness (ET) of the central cornea and limbal regions in patients with limbal stem cell deficiency (LSCD) as a diagnostic and staging parameter. DESIGN: Prospective, cross-sectional study. METHODS: The central corneal epithelium thickness (CET) and maximum limbal epithelium thickness (mLET) were measured in the superior, inferior, nasal, and temporal limbus on AS-OCT images of the normal and eyes with LSCD. CET was obtained by 1-point (OCT-CET1) and 3-point measurement (OCT-CET3). The values of OCT-CET1 and OCT-CET3 were compared to the CET obtained with in vivo confocal microscopy (IVCM-CET). RESULTS: Sixty-eight eyes of 50 patients with LSCD and 52 eyes of 34 normal subjects were included. The mean (+/- standard deviation) OCT-CET3 was 55.0 +/- 3.0 mm (range, 50.6-62.0 mm) in the control group and 41.6 +/- 10.8 mm (range, 0-56.3 mm) in the LSCD group (P < .001). OCT-CET3 had a better correlation with IVCM-CET (r = 0.91) than did OCT-CET1 (r = 0.87, P = .001). The degree of reduction in OCTCET3 increased in more advanced clinical stages of LSCD (all P < .001). The OCT-CET3 cutoff value that suggests LSCD was 46.6 mm. Compared with the control group, the LSCD group had decreases in mLET in all 4 limbal regions (all P < .001). The sensitivity and specificity of OCT-CET3 is the highest among all mLET in detecting LSCD. CONCLUSIONS: Both CET and mLET were thinner in patients with LSCD than in normal subjects. OCTCET3 appears to be a reliable parameter to confirm LSCD when there is clinical suspicion. (c) 2020 Elsevier Inc. All rights reserved.)
基金：
RESEARCH TO PREVENT BLINDness
to the Department of Ophthalmology at the University of California, Los Angeles. Sophie X. Deng received grant support from the National Eye
Institute (2R01 EY021797 and R01 EY028557) and California Institute for Regenerative Medicine (TR2-01768, CLIN1-08686, CLIN2-11650).
第一作者机构：[1]Univ Calif Los Angeles, David Geffen Sch Med, Stein Eye Inst, 100 Stein Plaza, Los Angeles, CA 90095 USA[3]Capital Med Univ, Beijing Inst Ophthalmol, Beijing Key Lab Ophthalmol & Visual Sci, Beijing Tongren Hosp,Beijing Tongren Eye Ctr, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Univ Calif Los Angeles, David Geffen Sch Med, Stein Eye Inst, 100 Stein Plaza, Los Angeles, CA 90095 USA[*1]Stein Eye Institute, David Geffen School of Medicine at UCLA, 100 Stein Plaza, Los Angeles, CA 90095, USA
推荐引用方式(GB/T 7714)：
Liang Qingfeng,Le Qihua,Cordova Daniel W.,et al.Corneal Epithelial Thickness Measured Using Anterior Segment Optical Coherence Tomography as a Diagnostic Parameter for Limbal Stem Cell Deficiency[J].AMERICAN JOURNAL OF OPHTHALMOLOGY.2020,216:132-139.doi:10.1016/j.ajo.2020.04.006.
APA：
Liang, Qingfeng,Le, Qihua,Cordova, Daniel W.,Tseng, Chi-Hong&Deng, Sophie X..(2020).Corneal Epithelial Thickness Measured Using Anterior Segment Optical Coherence Tomography as a Diagnostic Parameter for Limbal Stem Cell Deficiency.AMERICAN JOURNAL OF OPHTHALMOLOGY,216,
MLA：
Liang, Qingfeng,et al."Corneal Epithelial Thickness Measured Using Anterior Segment Optical Coherence Tomography as a Diagnostic Parameter for Limbal Stem Cell Deficiency".AMERICAN JOURNAL OF OPHTHALMOLOGY 216.(2020):132-139
医学