Accumulating evidence suggests that botulinum neurotoxins (BoNTs), which inhibit acetylcholine release, can be used for treating plaque psoriasis. The therapeutic effects of scopolamine occur through antagonism of central muscarinic acetylcholine receptors. Thus, scopolamine has potential for the treatment of psoriasis. We aimed to evaluate the efficacy and safety of scopolamine plus propofol for the treatment of recalcitrant psoriasis. Twelve patients with recalcitrant psoriasis were enrolled. Patients received intravenous injection of scopolamine plus propofol for 5 consecutive days per month for a total of 3 months. Clinical efficacy was evaluated using a Psoriasis Area and Severity Index (PASI) score. Efficacy outcome was >= 75% reduction in PASI score (PASI75) from baseline. Two patients were lost to follow-up. At week 8, two of 10 patients (20%) achieved PASI75, and at week 12, seven of 10 (70%) achieved PASI75. Treatment was well tolerated, with no reported adverse events. Our study revealed the efficacy and safety of scopolamine plus propofol for the treatment of recalcitrant psoriasis. Scopolamine plus propofol therapy may be a new treatment for recalcitrant psoriasis.
基金：
Ruijin Hospital Shanghai Jiaotong University School of Medicine, China [2018CR007]
第一作者机构：[1]Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Anesthesiol, Shanghai 200020, Peoples R China[2]Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Curat Anesthesia,LuWan Branch, Shanghai, Peoples R China
通讯作者：
通讯机构：[1]Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Anesthesiol, Shanghai 200020, Peoples R China[*1]Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200020, China.
推荐引用方式(GB/T 7714)：
Li Qifang,Li Mengya,Li Guifeng,et al.Efficacy of scopolamine plus propofol in the treatment of recalcitrant psoriasis: A pilot study[J].DERMATOLOGIC THERAPY.2021,34(2):doi:10.1111/dth.14866.
APA：
Li, Qifang,Li, Mengya,Li, Guifeng,Cai, Qing,Song, Ningjing...&Yu, Buwei.(2021).Efficacy of scopolamine plus propofol in the treatment of recalcitrant psoriasis: A pilot study.DERMATOLOGIC THERAPY,34,(2)
MLA：
Li, Qifang,et al."Efficacy of scopolamine plus propofol in the treatment of recalcitrant psoriasis: A pilot study".DERMATOLOGIC THERAPY 34..2(2021)
