研究单位：[1]Shenyang Northern Hospital[2]The General Hospital of Northern Theater Command,Shenyang Northern Hospital[3]Anhui Provincial Hospital,Hefei 1808722,Anhui 1818058,China,230001[4]The Seventh Medical Center of Pla General Hospital,Beijing 1816670,Beijing Municipality 2038349,China,100010[5]Beijing Anzhen Hospital,Capital Medical University, word2,Beijing 1816670,Beijing Municipality 2038349,China,100029[6]Beijing Anzhen Hospital,Capital Medical University, word3,Beijing 1816670,Beijing Municipality 2038349,China,100029[7]PLA Rocket Force Characteristic Medical Center,Beijing 1816670,Beijing Municipality 2038349,China,100088[8]Peking University International Hospital,Beijing 1816670,Beijing Municipality 2038349,China,102206[9]Beijing Tsinghua Changgung Hospital,Beijing 1816670,Beijing Municipality 2038349,China,102218[10]Xinqiao Hospital Army Medical University,Chongqing 1814906,Chongqing Municipality 1814905,China,400037[11]Department of Cardiology, Daping Hospital, The Third Military Medical University,Chongqing 1814906,Chongqing Municipality 1814905,China,400042[12]University-Town Hospital Of Chongqing Medical University,Chongqing 1814906,Chongqing Municipality 1814905,China,401331[13]Fujian Medical University Union Hospital,Fuzhou 1810821,Fujian 1811017,China,350001[14]Fujian Provincial Hospital,Fuzhou 1810821,Fujian 1811017,China,350001[15]Guangdong General Hospital,Guangzhou 1809858,Guangdong 1809935,China,510080[16]The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 1809858,Guangdong 1809935,China,510080[17]Guangzhou Red Cross Hospital,Guangzhou 1809858,Guangdong 1809935,China,510235[18]Meizhou People''s Hospital,Meizhou 1800779,Guangdong 1809935,China,514031[19]Fuwai Hospital Chinese Academy Of Medical Sciences, Shenzhen,Shenzhen 1795565,Guangdong 1809935,China,518057[20]Zhongshan City People''s Hospital,Zhongshan 6986104,Guangdong 1809935,China,528403[21]Liuzhou Worker''s Hospital,Liuzhou 1803300,Guangxi 1809867,China,545007[22]Cangzhou Central Hospital,Cangzhou 1816080,Hebei 1808773,China,061011[23]The First Hospital Of Hebei Medical University,Shijiazhuang 1795270,Hebei 1808773,China,050000[24]The Second Hospital Of Hebei Medical University,Shijiazhuang 1795270,Hebei 1808773,China,050000[25]Shijiazhuang People''s Hospital,Shijiazhuang 1795270,Hebei 1808773,China,050030[26]Bethune International Peace Hospital,Shijiazhuang 1795270,Hebei 1808773,China,050051[27]Xinxiang Central Hospital,Xinxiang 1788572,Henan 1808520,China,453099[28]The First Affiliated Hospital Of Zhengzhou University,Zhengzhou 1784658,Henan 1808520,China,450052[29]Fuwai Central China Cardiovascular Hospital,Zhengzhou 1784658,Henan 1808520,China,451460[30]Wuhan Asia Heart Hospital,Wuhan 1791247,Hubei 1806949,China,430022[31]Wuhan Union Hospital China,Wuhan 1791247,Hubei 1806949,China,430022[32]Tongji Medical College Of Hust,Wuhan 1791247,Hubei 1806949,China,430030[33]People''s Hospital Of Hunan Province,Changsha 1815577,Hunan 1806691,China,410005[34]The Third Xiangya Hospital Of Central South University,Changsha 1815577,Hunan 1806691,China,410205[35]Inner Mongolia People''s Hospital,Hohhot 2036892,Inner Mongolia 2035607,China,010017[36]HulunBuir People''s Hospital,Hulun Buir 12548253,Inner Mongolia 2035607,China,021008[37]Inner Mongolia Forestry General Hospital,Hulun Buir 12548253,Inner Mongolia 2035607,China,022150[38]Nanjing First Hospital,Nanjing 1799962,Jiangsu 1806260,China,210006[39]Nanjing Drum Tower Hospital,Nanjing 1799962,Jiangsu 1806260,China,210008[40]Zhongda Hospital Southeast University,Nanjing 1799962,Jiangsu 1806260,China,210009[41]Nanjing Jinling Hospital,Nanjing 1799962,Jiangsu 1806260,China,210016[42]Jiangsu Province Hospital,Nanjing 1799962,Jiangsu 1806260,China,210029[43]The First Affiliated Hospital Of Soochow University,Suzhou 1886760,Jiangsu 1806260,China,215031[44]Xuzhou Cancer Hospital,Xuzhou 10630003,Jiangsu 1806260,China,221005[45]The Second Affiliated Hospital Of Xuzhou Medical University,Xuzhou 10630003,Jiangsu 1806260,China,221006[46]The First Bethune Hospital Of Jilin University,Changchun 2038180,Jilin 2036500,China,130021[47]China-Japan Union Hospital Of Jilin University,Changchun 2038180,Jilin 2036500,China,130033[48]The Second Hospital Of Jilin University,Changchun 2038180,Jilin 2036500,China,130041[49]Jilin Central General Hospital,Jilin 2036502,Jilin 2036500,China,132011[50]Jilin City Hospital Of Chemical Industry, word1,Jilin 2036502,Jilin 2036500,China,132021[51]Jilin City Hospital Of Chemical Industry, word2,Jilin 2036502,Jilin 2036500,China,132021[52]Meihekou Central Hospital,Meihekou 2035801,Jilin 2036500,China,135099[53]Siping First People''s Hospital,Siping 2034714,Jilin 2036500,China,136001[54]Anshan Center Hospital,Anshan 2038632,Liaoning 2036115,China,114008[55]Benxi Central Hospital,Benxi 2038300,Liaoning 2036115,China,117099[56]The First Affiliated Hospital Of Dalian Medical University,Dalian 1814087,Liaoning 2036115,China,116011[57]The Second Hospital Of Dalian Medical University,Dalian 1814087,Liaoning 2036115,China,116023[58]Dalian Friendship Hospital,Dalian 1814087,Liaoning 2036115,China,116100[59]Dandong Central Hospital,Dandong 2037886,Liaoning 2036115,China,118002[60]The First Affiliated Hospital Of Liaoning University Of Traditional Chinese Medicine,Shenyang 2034937,Liaoning 2036115,China,110000[61]The First Hospital Of China Medical University,Shenyang 2034937,Liaoning 2036115,China,110002[62]The Second Affiliated Hospital of Shenyang Medical College,Shenyang 2034937,Liaoning 2036115,China,110002[63]Shengjing Hospital Of China Medical University,Shenyang 2034937,Liaoning 2036115,China,110004[64]General Hospital of Northern Theater Command,Shenyang 2034937,Liaoning 2036115,China,110016[65]The Fourth Affiliated Hospital Of China Medical University,Shenyang 2034937,Liaoning 2036115,China,110033[66]The People''s Hospital Of Liaoning Province,Shenyang 2034937,Liaoning 2036115,China,110067[67]Yingkou Central Hospital, word1,Yingkou 2033370,Liaoning 2036115,China,115003[68]Yingkou Central Hospital, word2,Yingkou 2033370,Liaoning 2036115,China,115003[69]The First Affiliated Hospital Of Baotou Medical College,Baotou 2038432,Neimonggol,China,014017[70]Baotou City Central Hospital,Baotou 2038432,Neimonggol,China,014040[71]Inner Mongolia People''s Hospital,Hohhot 2036892,Neimonggol,China,010017[72]The First Affiliated Hospital Of Xi''an Jiaotong University,Xi''an 1790630,Shaanxi 1796480,China,710061[73]Shaanxi Provincial People''s Hospital,Xi''an 1790630,Shaanxi 1796480,China,710068[74]Central Hospital Affiliated To Shandong First Medical University,Jinan 1805753,Shandong 1796328,China,250013[75]The General Hospital Of Jinan Military Command,Jinan 1805753,Shandong 1796328,China,250031[76]Qilu Hospital Of Shandong University,Jinan 1805753,Shandong 1796328,China,250063[77]Weihai Municipal Hospital,Weihai 1791673,Shandong 1796328,China,264299[78]Shanghai Ninth People''s Hospital, Shanghai Jiaotong University School Of Medicine,Shanghai 1796236,Shanghai Municipality 1796231,China,200011[79]Ruijin Hospital, Shanghai Jiaotong University School of Medicine,Shanghai 1796236,Shanghai Municipality 1796231,China,200020[80]Zhongshan Hospital,Shanghai 1796236,Shanghai Municipality 1796231,China,200032[81]Huashan Hospital,Fudan University,Shanghai 1796236,Shanghai Municipality 1796231,China,200040[82]Shanghai Tenth People''s Hospital,Shanghai 1796236,Shanghai Municipality 1796231,China,200072[84]Changhai Hospital,Shanghai 1796236,Shanghai Municipality 1796231,China,200433[85]Linfen Central Hospital,Linfen 1803567,Shanxi 1795912,China,041099[86]Shanxi Cardiovascular Hospital,Taiyuan 1793511,Shanxi 1795912,China,030024[87]Yuncheng Central Hospital,Yuncheng 1785738,Shanxi 1795912,China,044099[88]West China Hospital, Sichuan University,Chengdu 1815286,Sichuan 1794299,China,610041[89]Sichuan Provincial People''s Hospita[90]Beijing Tongren Hospital,CMU,Beijing 1816670,China,100730
研究目的：
Current guidelines recommend that patients with ACS undergoing stent implantation might be offered extended DAPT treatment for up to 30 months if necessary. Therefore, we designed a prospective, multicenter, randomized, placebo-controlled trial among ACS patients with high-risk on ischemic and bleeding who received a new generation of DES and received 9 to 12 months of DAPT, and evaluated whether clopidogrel monotherapy reduce the risk of bleeding compared with clopidogrel plus ASA in the following 9 months and achieved non-inferior outcomes in preventing ischemic risk.
