The aim of this study was to compare the repeatability of optical coherence tomography angiography (OCT-A) measurements of macular vessel density using four OCT-A systems, including Heidelberg Spectralis HRA, Optovue RTVue XR, Zeiss Cirrus HD-OCT 5000, and Topcon DRI OCT Triton. A cross-sectional design was used for this study. The vascular density and vascular length density of the superficial and deep retinal capillary plexuses were imaged with OCT-A using 3 mm and 6 mm scan patterns and were calculated using ImageJ. Comparisons of intraclass correlation coefficients (ICC) were conducted. We found that the OCT-A systems had various levels of repeatability. Zeiss had better repeatability for vessel density than the other systems (overall ICC = 0.936). Optovue had better repeatability for vessel length density when the 6 mm scan pattern was used (ICC = 0.680 and 0.700 for retinal superficial and deep capillary plexus, respectively). We concluded that repeatability varied when different scan patterns of various OCT-A systems were used for imaging the superficial retinal and deep capillary plexuses. Results should be seen as valid only for a given method. The repeatability of various OCT-A systems should be considered in clinical practice and in clinical trials that use OCT-A metrics as outcome measures.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区眼科学
最新[2025]版：
大类|4 区医学
小类|4 区眼科学
JCR分区：
出版当年[2017]版：
Q3OPHTHALMOLOGYQ4MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Ophthalmol, Beijing 100730, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Ophthalmol, Beijing 100730, Peoples R China[*1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Ophthalmol, Beijing 100730, Peoples R China
推荐引用方式(GB/T 7714)：
Yang Jingyuan,Yuan Mingzhen,Wang Erqian,et al.Comparison of the Repeatability of Macular Vascular Density Measurements Using Four Optical Coherence Tomography Angiography Systems[J].JOURNAL OF OPHTHALMOLOGY.2019,2019:4372580.doi:10.1155/2019/4372580.
APA：
Yang, Jingyuan,Yuan, Mingzhen,Wang, Erqian&Chen, Youxin.(2019).Comparison of the Repeatability of Macular Vascular Density Measurements Using Four Optical Coherence Tomography Angiography Systems.JOURNAL OF OPHTHALMOLOGY,2019,
MLA：
Yang, Jingyuan,et al."Comparison of the Repeatability of Macular Vascular Density Measurements Using Four Optical Coherence Tomography Angiography Systems".JOURNAL OF OPHTHALMOLOGY 2019.(2019)
