机构：[1]Fujian Normal Univ, Coll Life Sci, Qishan Campus, Fuzhou, Fujian Province, Peoples R China[2]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Fujian Province, Peoples R China[3]Natl Yang Ming Univ, Dept Biotechnol, Taipei 112, Taiwan[4]Natl Yang Ming Univ, Lab Sci Med, Taipei 112, Taiwan
With the rapid development of targeted therapy and our understanding of the underlying molecular mechanisms, drug repurposing is becoming trendy in drug development field. Drugs that display promising therapeutic effects towards multiple diseases tend to target important signaling proteins. Insulin resistance and obesity are strongly associated and both are reported to be correlated with cancer, suggesting they may be linked via some critical pathways. Signal transducer and activator of transcription 1 (STAT1) is an important transcription factor involved in the regulation of multiple cellular processes such as proliferation, survival, inflammation, and angiogenesis. The expression and activity of STAT1 is misregulated in both insulin resistance diseases and cancer. In this review, we summarize recent progress on the function and regulation of STAT1 in both cancer and insulin resistance diseases. Drugs and small molecules that can interfere with STAT1 activity or expression are also discussed.
基金：
National Natural Science Foundation of China [31640053]; Natural Science Foundation of Fujian Province [2016Y0029]
第一作者机构：[1]Fujian Normal Univ, Coll Life Sci, Qishan Campus, Fuzhou, Fujian Province, Peoples R China
通讯作者：
通讯机构：[1]Fujian Normal Univ, Coll Life Sci, Qishan Campus, Fuzhou, Fujian Province, Peoples R China[*1]Fujian Normal Univ, Coll Life Sci, Qishan Campus, Fuzhou, Fujian Province, Peoples R China[2]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Fujian Province, Peoples R China[*2]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Fujian Province, Peoples R China[3]Natl Yang Ming Univ, Dept Biotechnol, Taipei 112, Taiwan[*3]Natl Yang Ming Univ, Dept Biotechnol, Taipei 112, Taiwan[4]Natl Yang Ming Univ, Lab Sci Med, Taipei 112, Taiwan[*4]Natl Yang Ming Univ, Lab Sci Med, Taipei 112, Taiwan
推荐引用方式(GB/T 7714)：
Meng Chen,Guo Li-bin,Liu Xiaolong,et al.Targeting STAT1 in Both Cancer and Insulin Resistance Diseases[J].CURRENT PROTEIN & PEPTIDE SCIENCE.2017,18(2):181-188.doi:10.2174/1389203718666161117114735.
APA：
Meng, Chen,Guo, Li-bin,Liu, Xiaolong,Chang, Yih-Hsin&Lin, Yao.(2017).Targeting STAT1 in Both Cancer and Insulin Resistance Diseases.CURRENT PROTEIN & PEPTIDE SCIENCE,18,(2)
MLA：
Meng, Chen,et al."Targeting STAT1 in Both Cancer and Insulin Resistance Diseases".CURRENT PROTEIN & PEPTIDE SCIENCE 18..2(2017):181-188
：