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Increased circulating CRTH2(+)Tregs are associated with asthma control and exacerbation

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机构: [1]Phramongkutklao Hosp, Dept Med, Div Allergy & Clin Immunol, Bangkok, Thailand [2]Mahidol Univ, Fac Med, Dept Med, Div Allergy Immunol & Rheumatol,Ramathibodi Hosp, Bangkok, Thailand [3]Srinakharinwirot Univ, Panyananthaphikkhu Chonprathan Med Ctr, Dept Med, Nonthaburi, Thailand [4]Phramongkutklao Coll Med, Dept Pharmacol, Bangkok, Thailand [5]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China [6]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China [7]Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland [8]Christine Kuhne Ctr Allergy Res & Educ CK CARE, Davos, Switzerland
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关键词: ALI culture allergic asthma asthma control test score asthma exacerbation CRTH2 epithelial tight junction PGD2 Treg cells Tregs dysfunction

摘要:
The frequency of CRTH2(+)Tregs in patients with asthma, especially allergic phenotype is higher compared to healthy controls and shows a negative correlation with ACT scores and PEFR. CRTH2(+)Tregs increase during exacerbation and decrease after asthma control. In vitro investigations demonstrate that Tregs of allergic patients with asthma display Th2-biased character. Abbreviation: CRTH2, chemoattractant receptor-homologous molecule expressed on Th2 cells; Tregs, regulatory T cells; ACT, asthma control test; PEFR, peak expiratory flow rate.

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出版当年[2021]版:
大类 | 1 区 医学
小类 | 1 区 过敏 1 区 免疫学
最新[2023]版:
大类 | 1 区 医学
小类 | 1 区 免疫学 2 区 过敏
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出版当年[2020]版:
Q1 IMMUNOLOGY Q1 ALLERGY
最新[2023]版:
Q1 ALLERGY Q1 IMMUNOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

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第一作者机构: [1]Phramongkutklao Hosp, Dept Med, Div Allergy & Clin Immunol, Bangkok, Thailand
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通讯机构: [1]Phramongkutklao Hosp, Dept Med, Div Allergy & Clin Immunol, Bangkok, Thailand [7]Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland [8]Christine Kuhne Ctr Allergy Res & Educ CK CARE, Davos, Switzerland [*1]Division of Allergy and Clinical Immunology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand
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