机构：[1]Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,[2]Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China,[3]Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Ruijin Hospital, Shanghai, China,[4]Department of Respiratory and Critical Care Medicine, Tongren Hospital Affiliated to Wuhan University, The Third Hospital of Wuhan, Wuhan, China
Obstructive sleep apnea (OSA) is regarded as an independent risk factor for hypertension. The possible mechanism includes oxidative stress, endothelial injury, sympathetic excitement, renin-angiotensin-aldosterone system activation, etc. Clinical studies have found that there is a high coexistence of OSA and primary aldosteronism in patients with hypertension and that elevated aldosterone levels are independently associated with OSA severity in resistant hypertension. The underlying mechanism is that aldosterone excess can exacerbate OSA through increasing overnight fluid shift and affecting the mass and function of upper airway muscles during the sleep period. Thus, a bidirectional influence between OSA and aldosterone exists and contributes to hypertension in OSA patients, especially resistant hypertension.
基金：
National Natural
Science Foundation of China (82070089, 81770084); Shanghai
Municipal Key Clinical Specialty (shslczdzk02202); Shanghai
Top-Priority Clinical Key Disciplines Construction Project
(2017ZZ02014); Shanghai Key Laboratory of Emergency
Prevention, Diagnosis and Treatment of Respiratory Infectious
Diseases (20dz2261100); and Cultivation Project of Shanghai
Major Infectious Disease Research Base (20dz2210500).
第一作者机构：[1]Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,[2]Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China,[3]Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Ruijin Hospital, Shanghai, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,[2]Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China,[3]Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Ruijin Hospital, Shanghai, China,
推荐引用方式(GB/T 7714)：
Wang Yi,Li Chuan Xiang,Lin Ying Ni,et al.The Role of Aldosterone in OSA and OSA-Related Hypertension[J].FRONTIERS IN ENDOCRINOLOGY.2022,12:doi:10.3389/fendo.2021.801689.
APA：
Wang, Yi,Li, Chuan Xiang,Lin, Ying Ni,Zhang, Li Yue,Li, Shi Qi...&Li, Qing Yun.(2022).The Role of Aldosterone in OSA and OSA-Related Hypertension.FRONTIERS IN ENDOCRINOLOGY,12,
MLA：
Wang, Yi,et al."The Role of Aldosterone in OSA and OSA-Related Hypertension".FRONTIERS IN ENDOCRINOLOGY 12.(2022)
