机构：[1]Department of Radiology Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Beijing 100730, China医技科室放射科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Radiology and Cognitive Imaging Research Center, Michigan State University, 846 Service Road, East Lansing, MI 48824, USA[3]Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100091, China[4]Beijing City Key Lab for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing 100091, China[5]McGovern Institution for Brain Research, Peking University, Beijing 100091, China[6]Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA
Adolescents with early profound deafness may present with distractibility and inattentiveness. The brain mechanisms underlying these attention impairments remain unclear. We performed resting-state functional magnetic resonance imaging to investigate the functional connectivity of the superior temporal and transverse temporal gyri in 25 inattentive adolescents with bilateral prelingual profound deafness, and compared the results with those of 27 age-matched normal controls. Pearson and Spearman's rho correlation analyses were used to investigate the correlations of altered functional connectivity with the clinical parameters, including the duration of hearing loss sign language, and hearing aid usage. Compared with normal controls, prelingual profound deafness demonstrated mainly decreased resting-state functional connectivity between the deprived auditory regions and several other brain functional networks, including the attention control, language comprehension, default-mode, and sensorimotor networks. Moreover, we also found enhanced resting-state functional connectivity between the deprived auditory cortex and salience network. These results indicate a negative impact of early hearing loss on the attentional and other high cognitive networks, and the use of sign language and hearing aids normalized the participants' connectivity between the primary auditory cortex and attention networks, which is crucial for the early intervention and clinical care of deaf adolescents.
基金：
National Natural Science Foundation of China [81501449]; Major Scientific Research Instrument Projects of the National Natural Science Foundation of China [81627901]; Beijing Brain Initiative of Beijing Municipal Science & Technology Commission [Z181100001518003]
第一作者机构：[1]Department of Radiology Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Beijing 100730, China[2]Department of Radiology and Cognitive Imaging Research Center, Michigan State University, 846 Service Road, East Lansing, MI 48824, USA
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推荐引用方式(GB/T 7714)：
Li Jianhong,Men Weiwei,Gao Jia-Hong,et al.Functional connectivity alteration of the deprived auditory regions with cognitive networks in deaf and inattentive adolescents[J].BRAIN IMAGING AND BEHAVIOR.2022,16(2):939-954.doi:10.1007/s11682-022-00632-x.
APA：
Li, Jianhong,Men, Weiwei,Gao, Jia-Hong,Wang, Yang,Qu, Xiaoxia...&Xian, Junfang.(2022).Functional connectivity alteration of the deprived auditory regions with cognitive networks in deaf and inattentive adolescents.BRAIN IMAGING AND BEHAVIOR,16,(2)
MLA：
Li, Jianhong,et al."Functional connectivity alteration of the deprived auditory regions with cognitive networks in deaf and inattentive adolescents".BRAIN IMAGING AND BEHAVIOR 16..2(2022):939-954
