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Reduced Functional and Anatomic Interhemispheric Homotopic Connectivity in Primary Open-Angle Glaucoma: A Combined Resting State-fMRI and DTI Study

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收录情况： ◇ SCIE

作者：
Wang, Qian[1] * ; Chen, Weiwei[2] * ; Wang, Huaizhou[2] ; Zhang, Xun[2] ; Qu, Xiaoxia[1] ; Ang, Ying[1] ; Li, Ting[1] ; Wang, Ningli[2,*1] ; Xian, Junfang[1,*2] ;
机构： [1]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China [2]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China
出处：
DOI： 10.1167/iovs.17-23291
ISSN：

关键词： functional magnetic resonance imaging resting state diffusion tensor imaging voxel mirrored homotopic connectivity primary open angle glaucoma

摘要：
PURPOSE. To investigate if abnormal interhemispheric homotopic functional connectivity were accompanied by corresponding anatomic connectivity changes in primary open-angle glaucoma (POAG) patients, and to relate connectivity changes with retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) thickness. METHODS. Resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) were performed in 16 POAG patients and 19 healthy controls. Indices of interhemispheric homotopic functional connectivity and the underlying anatomic connectivity changes were derived with voxel-base whole-brain voxel-mirrored homotopic connectivity (VMHC) analyses and VMHC-guided probabilistic tractography. Pearson correlation analyses were used to explore the correlations between interhemispheric homotopic functional connectivity changes and anatomic connectivity alterations, and RNFL and GCC thickness. RESULTS. Reduced VMHC values between bilateral homotopic cortical areas located in Brodmann area (BA) 17, BA18, and BA19. Decreased anatomic connectivity connecting bilateral visual cortical areas inside BA17 and BA18 were observed in POAG patients. Furthermore, positive correlations between average RNFL thickness and reduced VMHC values of BA17 (r = 0.572, P = 0.021)/BA18 (r = 0.600, P = 0.014)/BA19 (r = 0.550, P = 0.027) are found using Pearson correlation analyses. CONCLUSIONS. Combinations of interhemispheric homotopic functional connectivity and anatomic connectivity changes may help to elucidate the mechanism of interhemispheric synchronization injury in POAG patients. Reduced VMHC values positively correlate with glaucomatous changes of RNFL thickness, which strengthens the hypothesis that POAG affects the visual cortex using a novel functional MRI characteristic.

基金：
National Natural Science Foundation of China under Grants 81571649, 81701666, and 81400391; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support under Grants ZYLX201704; High Level Health Technical Personnel of Bureau of Health in Beijing under Grants 2014-2-005 and Beijing Municipal Administration of Hospital’s Youth Programme under Grants QML20160203.
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 2 区 医学
小类 | 2 区 眼科学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 眼科学
JCR分区：
出版当年[2016]版：
Q1 OPHTHALMOLOGY
最新[2023]版：
Q1 OPHTHALMOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China [2]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China [*1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, No.1 Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China [*2]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, No. 1 of Dongjiaominxiang Street, Dongcheng District, Beijing 100730, Chin
推荐引用方式(GB/T 7714)：
Wang Qian,Chen Weiwei,Wang Huaizhou,et al.Reduced Functional and Anatomic Interhemispheric Homotopic Connectivity in Primary Open-Angle Glaucoma: A Combined Resting State-fMRI and DTI Study[J].INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2018,59(5):1861-1868.doi:10.1167/iovs.17-23291.
APA：
Wang, Qian,Chen, Weiwei,Wang, Huaizhou,Zhang, Xun,Qu, Xiaoxia...&Xian, Junfang.(2018).Reduced Functional and Anatomic Interhemispheric Homotopic Connectivity in Primary Open-Angle Glaucoma: A Combined Resting State-fMRI and DTI Study.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,59,(5)
MLA：
Wang, Qian,et al."Reduced Functional and Anatomic Interhemispheric Homotopic Connectivity in Primary Open-Angle Glaucoma: A Combined Resting State-fMRI and DTI Study".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 59..5(2018):1861-1868

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