机构：[1]School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Eastern HuaLan Avenue, Xinxiang 453003, Henan, People’s Republic of China[2]Department of Urology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No 1111 Xianxia Rd, Shanghai 200336, People’s Republic of China[3]School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223003, People’s Republic of China
Polyimide is a promising shell polymer for platinum electrodes because of good biocompatibility, excellent corrosion resistance, mechanical, thermal and chemical stabilities. Herein, hydroxyapatite (HAP) nanoparticles were coated on polyimide encapsulated platinum electrodes to overcome the adverse effects of electrical stimulation. SEM, TEM, XRD and EDS analyses indicated that the coating was homogeneous and dense consisting of nano-hydroxyapatite. The HAP/polyimide coating presented good stability under the conditions of moist heat, high temperature or high shear stress (10 dyn/cm(2)). Differential thermal analysis revealed that the nano-hydroxyapatite coating could significantly reduce the thermal diffusion from electrical stimulation its thermal elimination rate was about 96 times and 310 times smaller than that of polyimide encapsulated platinum electrode and bare platinum electrode, respectively. Atomic absorption spectroscopy measurement showed that the nano-hydroxyapatite coatings could prohibit the diffusion of platinum ions caused by electrical stimulation. CCK-8 test, neutral red uptake measurement and Tunel analysis revealed that the nano-hydroxyapatite coating could significantly attenuate the cytotoxicity of heavy metal ion from long-term stimulation. The in vivo biocompatibility evaluation by H&E measurement in a rabbit subcutaneous implantation model clearly showed that the nano-hydroxyapatite coating had good tissue response in 6 months. All these data supported that the nano-hydroxyapatite coating improved the biocompatibility of platinum electrodes by prohibiting thermal injury and heavy metal ions diffusion.
基金：
Basic Research Project of Natural Science in Henan Institute of Science and Technology [103010620002/012]; Med-Engineering Cross Foundation of Shanghai Jiao tong University [YG2019QNB28]; Scientific and technological project of Henan Province [222102310005]; Training Program of the National Natural Science Foundation of China in Henan Institute of Science and Technology [105020221015/034]; Training Program of Basic Research Plan in Henan Institute of Science and Technology [10502022015/056]
第一作者机构：[1]School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Eastern HuaLan Avenue, Xinxiang 453003, Henan, People’s Republic of China
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推荐引用方式(GB/T 7714)：
Wang Hua-Jie,Yang Gang-Gang,Zhang Jia-Min,et al.Hydroxyapatite nanoparticles/polyimide-coated platinum electrodes for improved heat-insulating and heavy metal ion diffusion properties[J].JOURNAL OF NANOSTRUCTURE IN CHEMISTRY.2023,13(6):563-575.doi:10.1007/s40097-022-00489-y.
APA：
Wang, Hua-Jie,Yang, Gang-Gang,Zhang, Jia-Min,Li, Shu-Mei&Bilal, Muhammad.(2023).Hydroxyapatite nanoparticles/polyimide-coated platinum electrodes for improved heat-insulating and heavy metal ion diffusion properties.JOURNAL OF NANOSTRUCTURE IN CHEMISTRY,13,(6)
MLA：
Wang, Hua-Jie,et al."Hydroxyapatite nanoparticles/polyimide-coated platinum electrodes for improved heat-insulating and heavy metal ion diffusion properties".JOURNAL OF NANOSTRUCTURE IN CHEMISTRY 13..6(2023):563-575
