机构：[1]Department of Otolaryngology Head and Neck Surgery, Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China,首都医科大学附属北京同仁医院临床科室耳鼻咽喉-头颈外科变态反应科[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China,首都医科大学附属北京同仁医院研究所耳鼻咽喉科研究所[3]Institute for Advanced Materials, Jiangsu University, Zhenjiang, China,[4]State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China,[5]Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Glucocorticoids are a class of steroid hormones secreted from the adrenal glands. The strong anti-inflammatory effects make it be one of the most popular and versatile drugs available to treat chronic inflammatory diseases. Additionally, supramolecular materials have been widely exploited in drug delivery, due to their biocompatibility, tunability, and predictability. Thus, steroid-based supramolecular materials and the release of steroids have been applied in the treatment of inflammatory diseases. This mini-review summarized recent advances in supramolecular materials loaded with glucocorticoid drugs in terms of hydrophobic interactions, electrostatic interactions, hydrogen bonding, and pi-pi stackings. We also discussed and prospected the application of the glucocorticoid drugs-based supramolecular system on chronic rhinosinusitis, multifactorial inflammatory disease of the nasal and paranasal sinuses mucosal membranes. Overall, supramolecular materials can provide an alternative to traditional materials as a novel delivery platform in clinical practice.
基金：
national key R and D program of China [2016YFC0905200]; program for the Changjiang scholars and innovative research teamProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT13082]; national natural science foundation of ChinaNational Natural Science Foundation of China (NSFC) [81630023, 81970852, 82000962]; Beijing Bai-Qian-Wan talent project [2019A32]; Public Welfare Development and Reform Pilot Project [2019-10]; National Science and Technology Major Project [2019ZX09201-005]; CAMS Innovation Fund for Medical Sciences [2019-I2M-5-022]
第一作者机构：[1]Department of Otolaryngology Head and Neck Surgery, Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China,[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China,
通讯作者：
通讯机构：[1]Department of Otolaryngology Head and Neck Surgery, Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China,[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China,[5]Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
推荐引用方式(GB/T 7714)：
Hao Yun,Zhang Feiyi,Mo Shanshan,et al.Biomedical Applications of Supramolecular Materials in the Controllable Delivery of Steroids[J].FRONTIERS IN MOLECULAR BIOSCIENCES.2021,8:doi:10.3389/fmolb.2021.700712.
APA：
Hao, Yun,Zhang, Feiyi,Mo, Shanshan,Zhao, Jinming,Wang, Xiangdong...&Zhang, Luo.(2021).Biomedical Applications of Supramolecular Materials in the Controllable Delivery of Steroids.FRONTIERS IN MOLECULAR BIOSCIENCES,8,
MLA：
Hao, Yun,et al."Biomedical Applications of Supramolecular Materials in the Controllable Delivery of Steroids".FRONTIERS IN MOLECULAR BIOSCIENCES 8.(2021)
