详情页 - 首都医科大学附属北京同仁医院知识库

当前位置：首页 > 详情页

Decreased histone expression in chronic rhinosinusitis with nasal polyps

2| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ ESCI

作者：

机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China. [2]Upper Airways Research Laboratory (URL), Department of Oto-Rhino-Laryngology, Ghent University Hospital, Ghent, Belgium. [3]Beijing key laboratory of nasal diseases, Beijing Institute of Otolaryngology, Beijing, China. [4]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.

出处：

DOI：

ISSN：

关键词： Apoptosis histones microarray analysis nasal polyps sinusitis

摘要：

Histones have been associated with human diseases. However, the implication of extranuclear histone proteins and their potential mechanism in the pathophysiology of chronic rhinosinusitis (CRS) have not been thoroughly investigated. This study was designed to evaluate the role of histones in patients with CRS by comparing histone expression between patients and controls.Nasal polyp (NP) tissues were obtained, and their comprehensive gene expression profiles were investigated by microarray analysis. Differences in expression were verified by reverse transcriptase polymerase chain reaction and immunohistochemical staining. Cell culture and flow cytometry were used to evaluate the role of histones in the pathogenesis of polyps.Significant differences in the microarray analysis were observed between the patient and control groups (P < 0.01). It was found by flow cytometry that the histone (H2BK) can promote cell apoptosis in NPs.Our results indicate that reduced expression of H2BK may contribute to the imbalance process of cell proliferation and apoptosis in CRS with NP.Copyright © 2024. Asia Pacific Association of Allergy, Asthma and Clinical Immunology.

基金：

语种：

WOS：

PubmedID：

JCR分区：

出版当年[2022]版：

无

最新[2023]版：

Q3 ALLERGY

影响因子： 1.6 最新[2023版] 1.7 最新五年平均 1.7 出版当年[2022版] 1.7 出版当年五年平均 0 出版前一年[2021版] 1.6 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.

通讯作者：

通讯机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China. [3]Beijing key laboratory of nasal diseases, Beijing Institute of Otolaryngology, Beijing, China. [4]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Decreased histone expression in chronic rhinosinusitis with nasal polyps [2]慢性鼻窦炎致病因素研究现状 [3]The Nasal Bacteria Microbiome Comparison Among Fungal Ball Sinusitis, Chronic Sinusitis with Polyps [4]1035例慢性鼻窦炎鼻息肉患者嗅觉功能测试结果的分析 [5]Use of biologics in chronic sinusitis with nasal polyps [6]MicroRNAs regulating mucin type O-glycan biosynthesis and transforming growth factor β signaling pathways in nasal mucosa of patients with chronic rhinosinusitis with nasal polyps in Northern China [7]219例慢性鼻窦炎、鼻息肉患者临床资料分析 [8]A Study of GR1802 in Participants With Chronic Sinusitis With Nasal Polyps [9]糖皮质激素诱导鼻息肉中嗜酸性粒细胞凋亡的体内和体外研究 [10]Presence and sequence of bronchiectasis onset impact on the clinical characteristics in asthmatic patients