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MicroRNAs regulating mucin type O-glycan biosynthesis and transforming growth factor β signaling pathways in nasal mucosa of patients with chronic rhinosinusitis with nasal polyps in Northern China

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Xuan, Lijia[1,2] * ; Luan, Ge[1,2] * ; Wang, Yue[1,2] ; Lan, Feng[1,2] ; Zhang, Xu[1,2] ; Hao, Yun[1,2] ; Zheng, Ming[1] ; Wang, Xiangdong[1,2] * ; Zhang, Luo[1,2,3,*1] * ;
机构： [1]Capital Med Univ, Beijing TongRen Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China [2]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China [3]Capita Med Univ, Beijing TongRen Hosp, Dept Allergy, Beijing, Peoples R China
出处：
DOI： 10.1002/alr.22230
ISSN：

关键词： CRSwNP microRNA microarray bioinformatics analysis KEGG

摘要：
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent sinonasal mucosa inflammatory disease. MicroRNAs (miRNAs) that are involved in the pathogenesis of CRSwNP in Northern China remain unknown. Methods A miRCURY (TM) LNA Array was used to analyze miRNA profiles in nasal mucosa tissues of CRSwNP patients (n = 19) and healthy controls (n = 10). Subsequent pathways were predicted by DIANA-mirPath software. Results Five upregulated miRNAs, including miR-210-5p, miR-3178, miR-585-3p, miR-3146, and miR-320e, and 19 downregulated miRNAs, including miR-32-3p, miR-1299, miR-3196, miR-3924, and miR-548e-3p, were differentially expressed (p < 0.05, fold change >2) in tissues of CRSwNP vs controls. Utilizing the Kyoto Encyclopedia of Genes and Genomes database (KEGG), which is an online database for pathway mapping, mucin type O-glycan biosynthesis pathway was significantly enriched in upregulated miRNAs. Transforming growth factor-beta (TGF-beta), transient receptor potential (TRP) channels, and the mitogen-activated protein kinase (MAPK) signaling pathway were significantly linked to downregulated miRNAs. Conclusion The mucin type O-glycan biosynthesis pathway and TGF-beta signaling pathway are regulated by miRNAs, which could be our focus in the future studies.

基金：
National Key R&D Program of China [2016YFC20160905200]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81420108009, 81630023, 81570894]; Changjiang Scholars and Innovative Research TeamProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT13082]; Beijing Talent Project (2016); Beijing Health Bureau Program for High Level Talents [2009-2-007, 2011-3-039, 2011-3-043, 2014-3-018]; Beijing Municipal Administration of Hospitals' Mission Plan [SML20150203]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7172054]; Beijing Talent Plan of Science and Technology [xxjc201712]; Beijing Scientific and Technological Overall Plan [Z171100000117002]

基金编号： 2016YFC20160905200 81420108009 81630023 81570894 IRT13082 2009-2-007 2011-3-039 2011-3-043 2014-3-018 SML20150203 7172054 xxjc201712 Z171100000117002

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 3 区 医学
小类 | 3 区 耳鼻喉科学
最新[2023]版：
大类 | 2 区 医学
小类 | 1 区 耳鼻喉科学
JCR分区：
出版当年[2017]版：
Q1 OTORHINOLARYNGOLOGY
最新[2023]版：
Q1 OTORHINOLARYNGOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]Capital Med Univ, Beijing TongRen Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China [2]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China
共同第一作者：
通讯作者：
通讯机构： [1]Capital Med Univ, Beijing TongRen Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China [2]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China [3]Capita Med Univ, Beijing TongRen Hosp, Dept Allergy, Beijing, Peoples R China [*1]Beijing TongRen Hosp, Beijing Inst Otolaryngol, 17 HouGouHuTong, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Xuan Lijia,Luan Ge,Wang Yue,et al.MicroRNAs regulating mucin type O-glycan biosynthesis and transforming growth factor β signaling pathways in nasal mucosa of patients with chronic rhinosinusitis with nasal polyps in Northern China[J].INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY.2019,9(1):106-113.doi:10.1002/alr.22230.
APA：
Xuan, Lijia,Luan, Ge,Wang, Yue,Lan, Feng,Zhang, Xu...&Zhang, Luo.(2019).MicroRNAs regulating mucin type O-glycan biosynthesis and transforming growth factor β signaling pathways in nasal mucosa of patients with chronic rhinosinusitis with nasal polyps in Northern China.INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY,9,(1)
MLA：
Xuan, Lijia,et al."MicroRNAs regulating mucin type O-glycan biosynthesis and transforming growth factor β signaling pathways in nasal mucosa of patients with chronic rhinosinusitis with nasal polyps in Northern China".INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY 9..1(2019):106-113

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