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Screening of the shared pathogenic genes of ulcerative colitis and colorectal cancer by integrated bioinformatics analysis

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收录情况： ◇ SCIE

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机构： [1]Department of Orthopaedics, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, China. [2]Department of Paediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Taicang Hospital of Traditional Chinese Medicine, Taicang, China. [3]Department of General Surgery, Siyang Hospital, Suqian, China. [4]Department of Obstetrics and Gynaecology, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China. [5]Department of Clinical Laboratory, Lianshui County People's Hospital, Huai'an, China.

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关键词： colorectal cancer immune-relatedgenes integrated bioinformatics analysis machine learning the shared pathogenic genes ulcerative colitis

摘要：

Ulcerative colitis (UC) is one of the high-risk pathogenic factors for colorectal cancer (CRC). However, the shared gene and signalling mechanisms between UC and CRC remain unclear. The goal of this study was to delve more into the probable causal relationship between UC and CRC. CRC and UC datasets were downloaded from the Gene Expression Omnibus database. Using R software and Perl, differentially expressed genes (DEGs) in both UC and CRC tissues were re-annotated and screened. The biological activities and signalling pathways involved in DEGs were investigated using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. The STRING database and Cytoscape software were used to construct the gene interaction network. A total of 384 DEGs were selected for further investigation, and functional analysis revealed that inflammatory and immunological responses were crucial in the development of the two diseases. Moreover, the top 15 key genes involved in the UC and CRC were screened using cytoHubba, including IL1B, CXCL10, CCL20, MMP9, ICAM1, CCL4, CXCR1, MMP3, TLR2, PTGS2, IL1RN, IL6, COL1A2, TIMP1 and CXCL1. The identification of these genes in the present study may provide a novel perspective for the prediction, prevention and personalized medicine of UC and CRC patients.© 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

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出版当年[2023]版：

大类 | 2 区

医学

小类 | 2 区医学：研究与实验 3 区细胞生物学

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区医学：研究与实验 3 区细胞生物学

JCR分区：

出版当年[2022]版：

Q2 CELL BIOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q2 CELL BIOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 4.3 最新[2023版] 5.1 最新五年平均 5.3 出版当年[2022版] 5.5 出版当年五年平均 5.295 出版前一年[2021版] 4.3 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Orthopaedics, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.

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通讯作者：

通讯机构： [3]Department of General Surgery, Siyang Hospital, Suqian, China. [5]Department of Clinical Laboratory, Lianshui County People's Hospital, Huai'an, China. [*1]Department of Clinical Laboratory, Lianshui County People's Hospital, Huai'an, 223400, China. [*2]Department of General Surgery, Siyang Hospital, Suqian, 223700, Jiangsu, China.

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