Circular RNAs (circRNAs) are a class of non-coding RNAs that participate in various biological processes. However, the function of circRNAs in neonatal hypoxic-ischemic encephalopathy (HIE) is not fully understood. In the present study, the differentially expressed circRNAs in the peripheral blood of neonates with HIE and control samples were characterized by a microarray assay. A total of 456 circRNAs were significantly differentially expressed in the peripheral blood of neonates with HIE, with 250 upregulated and 206 downregulated circRNAs in HIE compared with the control samples. Reverse transcription-quantitative PCR was used to investigate specific circRNAs. Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes pathway analyses were used to determine the function of the parent genes of the dysregulated circRNAs. In addition, microRNAs that may be associated with specific circRNAs were predicted using miRanda. Collectively, the present results indicated the potential importance of circRNAs in the peripheral blood of neonates with HIE.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81801503]; Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK20180286]
第一作者机构：[1]Yangzhou Univ, Dept Pediat, Jingjiang Peoples Hosp, 28 Zhongzhou Rd, Jingjiang 214500, Jiangsu, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Yangzhou Univ, Dept Pediat, Jingjiang Peoples Hosp, 28 Zhongzhou Rd, Jingjiang 214500, Jiangsu, Peoples R China[*1]Department of Pediatric, Jingjiang People's Hospital Affiliated to Yangzhou University, 28 Zhongzhou Road, Jingjiang, Jiangsu 214500, P.R. China
推荐引用方式(GB/T 7714)：
Dong Xiaohua,Zhuang Sisi,Huang Yun,et al.Expression profile of circular RNAs in the peripheral blood of neonates with hypoxic-ischemic encephalopathy[J].MOLECULAR MEDICINE REPORTS.2020,22(1):87-96.doi:10.3892/mmr.2020.11091.
APA：
Dong, Xiaohua,Zhuang, Sisi,Huang, Yun,Yang, Xiaojing,Fu, Yanrong...&Zhao, Yingmin.(2020).Expression profile of circular RNAs in the peripheral blood of neonates with hypoxic-ischemic encephalopathy.MOLECULAR MEDICINE REPORTS,22,(1)
MLA：
Dong, Xiaohua,et al."Expression profile of circular RNAs in the peripheral blood of neonates with hypoxic-ischemic encephalopathy".MOLECULAR MEDICINE REPORTS 22..1(2020):87-96
