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LINC00938 alleviates hypoxia ischemia encephalopathy induced neonatal brain injury by regulating oxidative stress and inhibiting JNK/p38 MAPK signaling pathway

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收录情况： ◇ SCIE

作者：
Zhao Jing[2,4] * ; Le Meini[1] * ; Li Jie[3] * ; Huang Qiong[4] ; Chen Haocong[1] ; Zhang Wenyi[1] ; Mao Huiwen[4] ; Sun Qing[5] ; Li Aiguo[5] ; Zhao Yingmin[6] ; Yu Lingling[6] ; Yi Mingjiang[1] ; Wang Jie[4] ; Li Xinyuan[3,*1] ; Zhang Guangming[1,*1] ; Ma Jun[2,*1] ; Dong Xiaohua[1,3,4,*1] ;
机构： [1]Department of Anesthesiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China [2]Department of General Practitioners, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China [3]Department of Neurosurgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 20033, China [4]Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China [5]Department of Pediatrics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 20033, China [6]Department of Pediatric, Jingjiang People's Hospital Affiliated to Yangzhou University, Jingjiang 214500, China
出处：
DOI： 10.1016/j.expneurol.2023.114449
ISSN：

关键词： LINC00938 Hypoxic–ischemic encephalopathy Cell apoptosis Oxidative stress MAPK signaling

摘要：
Hypoxic-ischemic encephalopathy (HIE) is an important factor leading to permanent damage of central nervous system (CNS) and even neonatal death. Long non-coding RNAs (lncRNAs) has been shown to get involved in the pathogenesis of nervous system diseases. LINC00938 is an intergenic lncRNA which is reported to be involved in neurodegenerative disease. However, the potential role of LINC00938 in nerve injury of neonatal HIE is undetermined. Here, we found that the expression of LINC00938 in the whole blood of neonates with HIE was downregulated compared with the non-HIE group. Functional study revealed that the expression of LINC00938 was significantly decreased in oxygen-glucose deprivation (OGD)-induced SH-SY5Y. Knockdown of LINC00938 induced the neural cell apoptosis by increased the protein level of Bax, Cleaved-Caspase3 and decreased the expression of Bcl-2. In addition, overexpression of LINC00938 prevented the apoptosis of SH-SY5Y from OGD injury. RNA-seq analysis showed that MAPK signaling was involved in the anti-apoptosis function of LINC00938. LINC00938 knockdown induced the activation of c-Jun-N-terminal kinase (JNK), p38 mitogen-activated protein kinase, and inhibited the activation of ERK signaling. However, LINC00938 play neuroprotective role in OGD-induced SH-SY5Y by suppression the phosphorylation of JNK and p38 MAPK rather than regulation of ERK signaling pathway. Further analyses illustrated that the cell apoptosis of neuronal cell was dependent on the elevation of reactive oxygen species (ROS) and result in mitochondria dysfunction in LINC00938 knockdown SH-SY5Y. Pretreated with ROS inhibitor N-acetylcysteine amide (NACA) dramatically suppressed LINC00938 knockdown induced oxidative stress and mitochondria dysfunction which induced cell apoptosis. In addition, NACA treatment significantly reduced the expression of p-JNK and p-p38 in OGD-induced SH-SY5Y. Furthermore, overexpression of LINC00938 displayed a notably neuroprotective effect by suppress central nervous system cell apoptosis via alleviating oxidative stress in CoCl2-induced hypoxic HIE model of zebrafish. Taken together, these results suggested that LINC00938 can act as a neuroprotective factor to inhibit oxidative stress and apoptosis of CNS under HIE conditions.Copyright © 2023. Published by Elsevier Inc.

基金：
This work was supported by the Natural Science Foundation of Shanghai under Grant no. 22ZR1457100 and 20ZR1451900, National Natural Science Foundation of China under Grant no. 81801503, 82101621 and 82201382, Shanghai Municipal Health Commission project under Grant no. 20214Y0432, Shanghai Jiao Tong University School of Medicine: Nursing Development Program under Grant no. hlqnrc2021, Research on cancer pain management model of community population in regional medical alliance (CNYZ04), Scientific research project of Shanghai Changning District Health Committee under Grant no. 20214Y014, Changning District Committee of Science and Technology of China Grant no. CNKW2020Y07, Taizhou Science and Technology Support Plan (Social Development) project under Grant no. SSF20200345.
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外文
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出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 神经科学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 神经科学
JCR分区：
出版当年[2021]版：
Q2 NEUROSCIENCES
最新[2023]版：
Q1 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [2]Department of General Practitioners, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China [4]Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Anesthesiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China [2]Department of General Practitioners, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China [3]Department of Neurosurgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 20033, China [4]Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China [*1]Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China.
推荐引用方式(GB/T 7714)：
Zhao Jing,Le Meini,Li Jie,et al.LINC00938 alleviates hypoxia ischemia encephalopathy induced neonatal brain injury by regulating oxidative stress and inhibiting JNK/p38 MAPK signaling pathway[J].EXPERIMENTAL NEUROLOGY.2023,367:doi:10.1016/j.expneurol.2023.114449.
APA：
Zhao Jing,Le Meini,Li Jie,Huang Qiong,Chen Haocong...&Dong Xiaohua.(2023).LINC00938 alleviates hypoxia ischemia encephalopathy induced neonatal brain injury by regulating oxidative stress and inhibiting JNK/p38 MAPK signaling pathway.EXPERIMENTAL NEUROLOGY,367,
MLA：
Zhao Jing,et al."LINC00938 alleviates hypoxia ischemia encephalopathy induced neonatal brain injury by regulating oxidative stress and inhibiting JNK/p38 MAPK signaling pathway".EXPERIMENTAL NEUROLOGY 367.(2023)

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