机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京同仁医院临床科室耳鼻咽喉-头颈外科[2]Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China.首都医科大学附属北京同仁医院研究所耳鼻咽喉科研究所[3]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.[4]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Matrix metalloproteinases (MMPs) are a group of enzymes that are essential in maintaining extracellular matrix (ECM) homeostasis, regulating inflammation and tissue remodeling. In chronic rhinosinusitis (CRS), the overexpression of certain MMPs can contribute to chronic nasal tissue inflammation, ECM remodeling, and tissue repair.This review provides a comprehensive overview of the biological characteristics and functions of the MMP family, particularly focusing on the expression and activity of MMPs in patients with CRS, and delves into their role in the pathogenesis of CRS and their potential as therapeutic targets.MMPs are important in tissue remodeling and have been implicated in the pathophysiology of CRS. Previous studies have shown that the expression of MMPs is upregulated in the nasal mucosa of patients with CRS and positively correlates with the severity of CRS. However, there is still a large gap in the research content of MMP in CRS, and the specific expression and pathogenic mechanism of MMP still need to be clarified. The significance and value of the ratio of MMP to tissue inhibitors of metalloproteinase (TIMP) in diseases still need to be demonstrated. Moreover, further studies are needed to assess the efficacy and safety of biologics that target MMPs in patients with CRS.
基金：
This work was supported by grants from National Natural Science
Foundation of China [81900917, 82171108, 82025010, 81870698 and
82301329]; Changjiang Scholars and Innovative Research Team
(IRT13082); CAMS Innovation Fund for Medical Sciences (2019-I2M
-5-022); Beijing Municipal Science and Technology Project
(Z181100001618002 and Z211100002921057); Capital’s Funds for Health
Improvement and Research (CFH2022-1-1091); Beijing Municipal
Administration of Hospitals’ Mission Plan (SML20150203); Beijing
Municipal Administration of Hospitals’ Dengfeng plan (DFL20190202);
Beijing Municipal Administration of Hospitals Incubating Program
(PX2024010) Beijing Municipal Public Welfare Development and Reform
Pilot Project for Medical Research Institutes (JYY2023-1).
第一作者机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.[2]Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China.[3]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.[2]Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China.[3]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.[4]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.[*1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing 100730, PR China
推荐引用方式(GB/T 7714)：
Huang Yuqing,Yan Bing,Meng Chen,et al.Matrix metalloproteinases in chronic rhinosinusitis[J].EXPERT REVIEW OF CLINICAL IMMUNOLOGY.2024,20(5):547-558.doi:10.1080/1744666X.2024.2302362.
APA：
Huang Yuqing,Yan Bing,Meng Chen,Zhang Luo&Wang Chengshuo.(2024).Matrix metalloproteinases in chronic rhinosinusitis.EXPERT REVIEW OF CLINICAL IMMUNOLOGY,20,(5)
MLA：
Huang Yuqing,et al."Matrix metalloproteinases in chronic rhinosinusitis".EXPERT REVIEW OF CLINICAL IMMUNOLOGY 20..5(2024):547-558
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