Controlled incorporation of bioactive hydroxyapatite (HA) into poly(lactic acid) (PLA) signifies a promising approach to design and development of biomedical-adaptive materials. Here we unravel a microwave-assisted biomineralization approach to synthesis of HA nanowhiskers (HANWs), which were characterized by well-controlled diameter (similar to 30 nm) and length (80 - 120 nm), combined with a desirable calcium - phosphorus ratio (Ca/P) of 1.67. A high-shear liquid dispersion (HSLD) method that provided a combination of high pressure (up to 50 kPa) and high shear rate approaching 10000s(-1) was established to fabricate homogeneous PLA/HANWs composites. In particular, upon incorporation of 30 wt % HANWs the tensile strength and elastic modulus of PLA-HA30 (76.7 MPa and 3.3 GPa) were elevated by 48% and 84% compared to those of pure PLA, respectively, as accompanied by a nearly 2-fold increase in the cell viability. This work paves a facile yet effective roadway to strong and osteoconductive PLA composites appealing for bone tissue repairing. [GRAPHICS] .
基金：
National Natural Science Foundation of China [52003292, 51803192]; Jiangsu Provincial Research Foundation for Basic Research [BK20200661]; China Postdoctoral Science Foundation [2020M681763]; Jiangsu Provincial Postdoctoral Research Foundation [2021K578C]; Fundamental Research Funds for the Central Universities [2021QN1115, 2020ZDPYMS]
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Endocrinol, Beijing, Peoples R China[2]Xuzhou Med Univ, Affiliated Hosp, Dept Endocrinol, Xuzhou, Jiangsu, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Endocrinol, Beijing, Peoples R China[3]China Univ Min & Technol, Sch Mat Sci & Phys, Xuzhou, Jiangsu, Peoples R China[4]Zhengzhou Univ Light Ind, Sch Mat & Chem Engn, State Lab Surface & Interface Sci & Technol, Zhengzhou, Peoples R China[*1]Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China[*2]School of Materials Science and Physics, China University of Mining and Technology, Xuzhou, China[*3]State Laboratory of Surface and Interface Science and Technology, School of Material and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou, China[*4]School of Materials Science and Physics, China University of Mining and Technology, Xuzhou, China
推荐引用方式(GB/T 7714)：
Zhou Dong-Mei,Shen Mengyuan,Ke Lv,et al.Strong and osteoconductive poly(lactic acid) biocomposites by high-shear liquid dispersion of hydroxyapatite nanowhiskers[J].NANOCOMPOSITES.2022,8(1):24-33.doi:10.1080/20550324.2022.2054212.
APA：
Zhou, Dong-Mei,Shen, Mengyuan,Ke, Lv,Zhang, Zi-Lin,Zhang, Kai-Zhe...&Xu, Huan.(2022).Strong and osteoconductive poly(lactic acid) biocomposites by high-shear liquid dispersion of hydroxyapatite nanowhiskers.NANOCOMPOSITES,8,(1)
MLA：
Zhou, Dong-Mei,et al."Strong and osteoconductive poly(lactic acid) biocomposites by high-shear liquid dispersion of hydroxyapatite nanowhiskers".NANOCOMPOSITES 8..1(2022):24-33
