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Evaluation of nuclear PGAM2 value in hepatocellular carcinoma prognosis

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机构: [1]Second Mil Med Univ, Dept ICU, Eastern Hepatobiliary Surg Hosp, Shanghai, Peoples R China [2]Second Mil Med Univ, Sch Basic Med Sci, Shanghai, Peoples R China [3]Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Pathol, Shanghai, Peoples R China [4]Shanghai Jiao Tong Univ, Sch Med, Dept Gynecol & Obstet, Shanghai, Peoples R China [5]Shanghai Jiao Tong Univ, Tongren Hosp, Dept Intervent, Sch Med, Shanghai, Peoples R China [6]Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Surg 1, 225 Changhai Rd, Shanghai 200082, Peoples R China
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关键词: formalin-fixed paraffin-embedded hepatocellular carcinoma immunohistochemitry nuclear optical density phosphoglycerate mutase

摘要:
Phosphoglycerate mutase (PGAM) is a critical enzyme in glycolysis. PGAM2 is abundant in several types of tissues and malignant tumours. However, there is limited information regarding their clinicopathological significance in dysplastic nodules and hepatocellular carcinoma (HCC). This study aims to investigate the prognostic value of PGAM2 as a new biomarker for HCC. The PGAM2 expression level was evaluated by immunohistochemistry in liver cirrhosis (n = 10), low-grade dysplastic nodules (n = 15), high-grade dysplastic nodules (n = 15) and HCCs (n = 20) and 178 pairs of HCC and adjacent peritumoral liver tissues. We selected X-tile software for counting cut-point based on the outcomes for prognosis analysis, and used Kaplan-Meier analysis and Cox regression analysis can assess the prognosis of clinicopathologic parameters. Nuclear PGAM2 was significantly overexpressed in peritumoral liver tissues compared with HCC tissues (P = 0.0010). Kaplan-Meier analyses of 178 HCC samples revealed that nuclear PGAM2's high expression level, but not cytoplasmic PGAM2, was significantly related to good overall survival rate (OS). In addition, univariate and multivariate Cox analyses indicated nuclear PGAM2 expression could be regarded as valuable predictors for OS in HCC. PGAM2 was highly expressed in HCC tissues than liver cirrhosis tissues, and nuclear PGAM2's high expression might demonstrate HCC patients have poor postoperative results. Thus, nuclear PGAM2 can be regarded as valuable predictors for OS in HCC patients after surgery.

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出版当年[2021]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 药学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 药学
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出版当年[2020]版:
Q4 ONCOLOGY Q4 PHARMACOLOGY & PHARMACY
最新[2023]版:
Q3 ONCOLOGY Q3 PHARMACOLOGY & PHARMACY

影响因子: 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

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第一作者机构: [1]Second Mil Med Univ, Dept ICU, Eastern Hepatobiliary Surg Hosp, Shanghai, Peoples R China
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通讯机构: [6]Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Surg 1, 225 Changhai Rd, Shanghai 200082, Peoples R China [*1]Department of First Surgery, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, 225 Changhai Road, Shanghai 200082, China
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