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Retinal Nerve Fiber Layer Thickness and Rim Area Profiles in Asians Pooled Analysis from the Asian Eye Epidemiology Consortium

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作者：
Majithia, Shivani[1] * ; Tham, Yih-Chung[1,2] * ; Chong, Crystal Chun Yuen[1] ; Yu, Marco[1,2] ; Cheung, Carol Y.[3] ; Bikbov, Mukharram M.[4] ; Kazakbaeva, Gyulli M.[4] ; Wang, Ningli[5] ; Hao, Jie[5] ; Cao, Kai[5] ; Wang, Ya Xing[5] ; Sasaki, Mariko[6] ; Ito, Yoshikazu[6] ; Wong, Ian Y.[7,8] ; Chan, Jonathan Cheuk-Hung[7] ; Khanna, Rohit C.[9,10,11] ; Marmamula, Srinivas[9,10,11,12] ; Nakano, Eri[13] ; Mori, Yuki[13] ; Aung, Tin[1,2,14] ; Wong, Tien Yin[1,2,14] ; Jonas, Jost B.[15,16,17] ; Miyake, Masahiro[13] ; Cheng, Ching-Yu[1,2,14,*1] ;
机构： [1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore. [2]Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Republic of Singapore. [3]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. [4]Ufa Eye Research Institute, Ufa, Bashkortostan, Russian Federation. [5]Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [6]Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan. [7]Department of Ophthalmology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China. [8]Department of Ophthalmology, The Hong Kong Sanatorium & Hospital, Hong Kong SAR, China. [9]Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care, L V Prasad Eye Institute, Hyderabad, India. [10]Brien Holden Eye Research Centre, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India. [11]School of Optometry and Vision Science, University of New South Wales, Sydney, Australia. [12]Wellcome Trust/Department of Biotechnology India Alliance Research Fellow, L V Prasad Eye Institute, Hyderabad, India. [13]Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan. [14]Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore. [15]Department of Ophthalmology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. [16]Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland. [17]Private Practice, Heidelberg, Germany.
出处：
DOI： 10.1016/j.ophtha.2021.11.022
ISSN：

关键词： Asian Neuroretinal rim area OCT Population-based Retinal nerve fiber layer

摘要：
Purpose: To evaluate ethnic variations, ocular and systemic determinants of retinal nerve fiber layer (RNFL) thickness, and neuroretinal rim area among Asians using a large consortium of population-based eye studies. Design: Cross-sectional pooled analysis. Participants: Twenty-two thousand four hundred thirty-six participants (22 436 eyes) from 10 population-based studies (in China, Hong Kong, India, Japan, Russia, and Singapore) of the Asian Eye Epidemiology Consortium. Methods: Participants 40 years of age or older without glaucoma were included. All participants underwent spectral-domain OCT imaging and systemic and ocular examinations. Data were pooled from each study. Multivariable regression was performed to evaluate interethnic differences, intermachine variations, and ocular and systemic factors associated with RNFL thickness and rim area, adjusting for age, gender, diabetes, intraocular pressure (IOP), spherical equivalent (SE), ethnicity, OCT model, and study group. When evaluating body mass index, smoking, and hypertension as exposures, these factors were additionally adjusted for in the model. Main Outcome Measures: Average RNFL thickness (in micrometers) and rim area (in square millimeters). Results: Indian and Japanese eyes have thinner RNFLs than those of other Asian ethnicities (beta values range, 7.31-12.76 mu m; P < 0.001 for all pairwise comparisons). Compared with measurements by Cirrus HD-OCT (Carl Zeiss Meditec, Inc), RNFL on average was 7.29 mu m thicker when measured by Spectralis (Heidelberg Engineering), 12.85 mu m thicker when measured by RS-3000 (NIDEK Co, Ltd), and 17.48 mu m thicker when measured by iVue/RTVue (Optovue, Inc) devices (all P < 0.001). Additionally, older age (per decade, p = -2.70), diabetes (beta= -0.72), higher IOP (per 1 mmHg, p = -0.07), more myopic SE (per diopter, p = -1.13), cardiovascular disease (beta= -0.94), and hypertension (beta= -0.68) were associated with thinner RNFL (all P <= 0.003). Similarly, older age (beta= -0.019), higher IOP (beta= -0.010), and more myopic SE (beta= -0.025) were associated with smaller rim area (all P < 0.001). Conclusions: In this large pooled analysis of Asian population studies, Indian and Japanese eyes were observed to have thinner RNFL profiles. These findings suggest the need for an ethnic-specific normative database to improve glaucoma detection. (C) 2021 by the American Academy of Ophthalmology

基金：
Supported by the National Medical Research Council, Singapore, Republic of Singapore (grant no.: NMRC/OFLCG/004a/2018).
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外文
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出版当年[2021]版：
大类 | 1 区 医学
小类 | 1 区 眼科学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 眼科学
JCR分区：
出版当年[2020]版：
Q1 OPHTHALMOLOGY
最新[2023]版：
Q1 OPHTHALMOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore.
共同第一作者：
通讯作者：
通讯机构： [1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore. [2]Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Republic of Singapore. [14]Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore. [*1]The Academia, 20 College Road, Discovery Tower, Level 6, Singapore 169856, Republic of Singapore.
推荐引用方式(GB/T 7714)：
Majithia Shivani,Tham Yih-Chung,Chong Crystal Chun Yuen,et al.Retinal Nerve Fiber Layer Thickness and Rim Area Profiles in Asians Pooled Analysis from the Asian Eye Epidemiology Consortium[J].OPHTHALMOLOGY.2022,129(5):552-561.doi:10.1016/j.ophtha.2021.11.022.
APA：
Majithia, Shivani,Tham, Yih-Chung,Chong, Crystal Chun Yuen,Yu, Marco,Cheung, Carol Y....&Cheng, Ching-Yu.(2022).Retinal Nerve Fiber Layer Thickness and Rim Area Profiles in Asians Pooled Analysis from the Asian Eye Epidemiology Consortium.OPHTHALMOLOGY,129,(5)
MLA：
Majithia, Shivani,et al."Retinal Nerve Fiber Layer Thickness and Rim Area Profiles in Asians Pooled Analysis from the Asian Eye Epidemiology Consortium".OPHTHALMOLOGY 129..5(2022):552-561

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