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Relationship of Retinal Nerve Fiber Layer Thickness and Retinal Vessel Calibers with Cognitive Impairment in the Asymptomatic Polyvascular Abnormalities Population

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收录情况： ◇ SCIE ◇ CSCD-C ◇ 卓越：梯队期刊

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机构： [1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China [2]China National Clinical Research Center for Neurological Diseases, Beijing 100070, China. [3]Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China. [4]Department of Cardiology, Kailuan Hospital, Tangshan 063001, Hebei, China.

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关键词： Retinal nerve fiber layer Cognitive impairment Polyvascular abnormality

摘要：

Cognitive impairment (CI) in older individuals has a high morbidity rate worldwide, with poor diagnostic methods and susceptible population identification. This study aimed to investigate the relationship between different retinal metrics and CI in a particular population, emphasizing polyvascular status.We collected information from the Asymptomatic Polyvascular Abnormalities Community Study on retinal vessel calibers, retinal nerve fiber layer (RNFL) thickness, and cognitive function of 3,785 participants, aged 40 years or older. Logistic regression was used to analyze the relationship between retinal metrics and cognitive function. Subgroups stratified by different vascular statuses were also analyzed.RNFL thickness was significantly thinner in the CI group (odds ratio: 0.973, 95% confidence interval: 0.953-0.994). In the subgroup analysis, the difference still existed in the non-intracranial arterial stenosis, non-extracranial carotid arterial stenosis, and peripheral arterial disease subgroups ( P < 0.05).A thin RNFL is associated with CI, especially in people with non-large vessel stenosis. The underlying small vessel change in RNFL and CI should be investigated in the future.Copyright © 2024 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 4 区环境科学 4 区公共卫生、环境卫生与职业卫生

最新[2023]版：

大类 | 3 区医学

小类 | 4 区环境科学 4 区公共卫生、环境卫生与职业卫生

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出版当年[2022]版：

Q2 ENVIRONMENTAL SCIENCES Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

最新[2023]版：

Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Q2 ENVIRONMENTAL SCIENCES

影响因子： 3 最新[2023版] 3.1 最新五年平均 3.5 出版当年[2022版] 3.6 出版当年五年平均 2.831 出版前一年[2021版] 3 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China [2]China National Clinical Research Center for Neurological Diseases, Beijing 100070, China.

通讯作者：

通讯机构： [1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China [2]China National Clinical Research Center for Neurological Diseases, Beijing 100070, China.

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