Purpose/aim: We investigated the regularity changes of the retinal nerve fiber layer (RNFL) and macular ganglion cell complex (mGCC) of the amnestic mild cognitive impairment (aMCI) patients in this prospective cohort study.Materials and methods: Twenty-four aMCI patients and 30 health controls, who are more than 60years old, were recruited into the study. The RNFL and the mGCC average thickness were measured with Fourier-domain optical coherence tomography (FD-OCT).Results: Compared with that in the controls, the intraocular pressure (IOP) was significantly lower in the aMCI patients. A significant decrease in RNFL thickness in superior temporal, temporal upper (TU), and temporal upper and lower (TL) (TU+TL) quadrants was found in the aMCI patients than in the controls. The average thickness of the mGCC was also significantly thinner in the aMCI patients than in the controls.Conclusions: Retinal degeneration in the aMCI patients detected by OCT together with lower IOP may indicate disease pathological progression.
基金：
Beijing Municipal Science & Technology Commission
(Z141107002514116), National Natural Science Foundation of China (Grant No. 31371007,
81430037, 30970823), Kallikrein Medical Research Program (Grant No. 201206006).
第一作者机构：[1]Capital Med Univ, Beijing Shijitan Hosp, Dept Ophthalmol, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Shijitan Hosp, Dept Ophthalmol, Beijing, Peoples R China[6]Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038 China[*1]Department of Ophthalmology Beijing Shijitan Hospital Capital Medical University, No. 10 Tieyi Rd, Yangfangdian, Haidian District Beijing 100038 P. R. China.
推荐引用方式(GB/T 7714)：
Wu Yue,Wang Xiao-Ni,Wang Ningli,et al.Regularity changes of the retinal nerve fiber layer and macular ganglion cell complex in patients with the amnestic mild cognitive impairment[J].INTERNATIONAL JOURNAL OF NEUROSCIENCE.2018,128(9):849-853.doi:10.1080/00207454.2018.1438428.
APA：
Wu, Yue,Wang, Xiao-Ni,Wang, Ningli,Han, Ying,Ma, Daqing&Lu, Yan.(2018).Regularity changes of the retinal nerve fiber layer and macular ganglion cell complex in patients with the amnestic mild cognitive impairment.INTERNATIONAL JOURNAL OF NEUROSCIENCE,128,(9)
MLA：
Wu, Yue,et al."Regularity changes of the retinal nerve fiber layer and macular ganglion cell complex in patients with the amnestic mild cognitive impairment".INTERNATIONAL JOURNAL OF NEUROSCIENCE 128..9(2018):849-853
