Although angiogenesis plays an important role in tumor growth and invasion, its role in the progression of olfactory neuroblastoma (ONB) has rarely been published. The aim of the present research was to analyze the prognostic role of microvessel density (MVD) in ONB and its association with clinicopathological parameters. 70 ONB cases were assessed for immunohistochemiand VEGFR2. The expression of CD105-MVD was negatively associated with histological grade and tumor Kadish stage, and its expression was positively correlated with the expression of VEGF/VEGFR2. Low expression of CD105-MVD and high tumor histological grade were strongly associated with poor survival. Thus, CD105-MVD was demonstrated to be a valuable independent prognostic indicator for ONB. MVD is expected to be useful as an important marker to distinguish tumor histological grade.
基金：
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding [ZYLX201814]; Beijing Municipal Education Commission [KZ201910025033]
第一作者机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Pathol, Key Lab Head & Neck Mol Diag Pathol, 1 Dongjiaominxiang St, Beijing 100730, Peoples R China[2]Capital Med Univ, Beijing LuHe Hosp, Dept Pathol, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Pathol, Key Lab Head & Neck Mol Diag Pathol, 1 Dongjiaominxiang St, Beijing 100730, Peoples R China[*1]Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Head and Neck Molecular Diagnosis Pathology, 1 Dongjiaominxiang Street, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Wu Linlin,An Jianduo,Liu Honggang.Prognostic value of microvessel density and its correlation with clinicopathological features in human olfactory neuroblastoma[J].CLINICAL NEUROPATHOLOGY.2022,41(3):114-121.doi:10.5414/NP301447.
APA：
Wu, Linlin,An, Jianduo&Liu, Honggang.(2022).Prognostic value of microvessel density and its correlation with clinicopathological features in human olfactory neuroblastoma.CLINICAL NEUROPATHOLOGY,41,(3)
MLA：
Wu, Linlin,et al."Prognostic value of microvessel density and its correlation with clinicopathological features in human olfactory neuroblastoma".CLINICAL NEUROPATHOLOGY 41..3(2022):114-121
