机构：[1]School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang, Henan 453003, China[2]Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions,Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China[3]Department of Urology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No 1111 Xianxia Rd, Shanghai 200336, China
Semiconductor nanomaterials not only bring great convenience to peoples lives but also become a potential hazard to human health. The purpose of this study was to evaluate the toxicity of CuS/CdS nanocomposites in hepatocytes and mice liver. The CuS/CdS semiconductor nanocomposites were synthesized by a biomimetic synthesis - ion exchange strategy. Nanosize was confirmed by high-resolution transmission electron microscopy and dynamic light scattering. The composition and physical properties were measured by powder X-ray diffraction, Fourier transform infrared spectra, atomic absorption spectroscopy, thermogravimetry-differential scanning calorimetry and zeta potential analysis. The results revealed that CuS/CdS nanocomposites had 8.7 nm diameter and negative potential. Ion exchange time could adjust the ratio of CuS and CdS in nanocomposites. The toxicological study revealed that CuS/CdS nanocomposites could be internalized into liver cells, inhibited endogenous defense system (e.g. GSH and SOD), induced the accumulation of oxidation products (e.g. ROS, GSSG and MDA), and caused hepatocyte apoptosis. The in vivo experiments in Balb/c mice showed that the experimental dose (4 mg/kg) didn't cause observable changes in mice behavior, physical activity and pathological characteristics, but the continuous accumulation of Cd2+ in the liver and kidney might be responsible for its long-term toxicity. (C) 2021 Elsevier B.V. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31000774, 20971039]; Program for Science & Technology Innovation Talents in Universities of Henan Province (HASTIT) [16HASTIT049]; Basic Research Project of Natural Science in Henan Institute of Science and Technology [103010620002/012]
第一作者机构：[1]School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang, Henan 453003, China
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推荐引用方式(GB/T 7714)：
Wang Hua-Jie,Yang Gang-Gang,Wu Sha-Sha,et al.Toxicity of CuS/CdS semiconductor nanocomposites to liver cells and mice liver[J].SCIENCE OF THE TOTAL ENVIRONMENT.2021,784:doi:10.1016/j.scitotenv.2021.147221.
APA：
Wang, Hua-Jie,Yang, Gang-Gang,Wu, Sha-Sha,Meng, Zhi-Fen,Zhang, Jia-Min...&Zhang, Yu-Ping.(2021).Toxicity of CuS/CdS semiconductor nanocomposites to liver cells and mice liver.SCIENCE OF THE TOTAL ENVIRONMENT,784,
MLA：
Wang, Hua-Jie,et al."Toxicity of CuS/CdS semiconductor nanocomposites to liver cells and mice liver".SCIENCE OF THE TOTAL ENVIRONMENT 784.(2021)
环境科学与生态学