机构:[1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore[2]Saw Swee Hock School of Public Health, National University of Singapore, Singapore[3]R&D Vision Sciences AMERA, Essilor International, Singapore[4]Eye Institute, Eye and ENT Hospital, Shanghai Medical College, Fudan University and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China[5]NHC Key Laboratory of Myopia, Fudan University, Shanghai, China[6]Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China[7]Duke-NUS Medical School, Singapore[8]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China[9]Hong Kong Eye Hospital, China, Hong Kong SAR[10]Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR, China[11]Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore[12]Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea[13]Department of Vitreoretina, Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India[14]Suraj Eye Institute, Nagpur, Maharashtra, India[15]Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[16]Ufa Eye Research Institute, Ufa, Bashkortostan, Russia[17]Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Aims To determine the prevalence and predictors of myopic macular degeneration (MMD) in a consortium of Asian studies. Methods Individual-level data from 19 885 participants from four population-based studies, and 1379 highly myopic participants (defined as axial length (AL) >26.0 mm) from three clinic-based/school-based studies of the Asian Eye Epidemiology Consortium were pooled. MMD was graded from fundus photographs following the meta-analysis for pathologic myopia classification and defined as the presence of diffuse choroidal atrophy, patchy chorioretinal atrophy, macular atrophy, with or without 'plus' lesion (lacquer crack, choroidal neovascularisation or Fuchs' spot). Area under the curve (AUC) evaluation for predictors was performed for the population-based studies. Results The prevalence of MMD was 0.4%, 0.5%, 1.5% and 5.2% among Asians in rural India, Beijing, Russia and Singapore, respectively. In the population-based studies, older age (per year; OR=1.13), female (OR=2.0), spherical equivalent (SE; per negative diopter; OR=1.7), longer AL (per mm; OR=3.1) and lower education (OR=1.9) were associated with MMD after multivariable adjustment (all p<0.001). Similarly, in the clinic-based/school-based studies, older age (OR=1.07; p<0.001), female (OR=2.1; p<0.001), longer AL (OR=2.1; p<0.001) and lower education (OR=1.7; p=0.005) were associated with MMD after multivariable adjustment. SE had the highest AUC of 0.92, followed by AL (AUC=0.87). The combination of SE, age, education and gender had a marginally higher AUC (0.94). Conclusion In this pooled analysis of multiple Asian studies, older age, female, lower education, greater myopia severity and longer AL were risk factors of MMD, and myopic SE was the strongest single predictor of MMD.
基金:
National Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC) [0796/2003, IRG07nov013, IRG09nov014, STaR/0003/2008, CG/SERI/2010]; Biomedical Research CouncilAgency for Science Technology & Research (ASTAR) [08/1/35/19/550, 09/1/35/19/616]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81870642, 81970780, 81570835]; Om Drishti Trust, Nagpur, India; Rotary Sight Saver Netherlands; Orbis, India; Carl Zeiss Meditec Co., Jena, Germany; General Research Fund, Research Grants Council, Hong Kong [14111515]; Health and Medical Research Fund, Hong Kong [5160836]; Direct Grants of the Chinese University of Hong Kong [4054193, 4054121, 4054199, 2018017]; Centaline Myopia Fund; CUHK Jockey Club Children Eye Care Programme; Shanghai High Myopia Study Group [NCT03062085]; Intelligent Medical Project of Shanghai Municipal Science and Technology Commission [2018ZHYL0220]; Economic Development Board-Essilor Post-graduate Programme, SingaporeSingapore Economic Development Board [S14-1103-IPP]; Heidelberg Engineering Co., Heidelberg, Germany
第一作者机构:[1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore[2]Saw Swee Hock School of Public Health, National University of Singapore, Singapore[3]R&D Vision Sciences AMERA, Essilor International, Singapore
通讯作者:
通讯机构:[1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore[2]Saw Swee Hock School of Public Health, National University of Singapore, Singapore[7]Duke-NUS Medical School, Singapore[11]Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore[*1]Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, Singapore 169856, Singapore
推荐引用方式(GB/T 7714):
Wong Yee Ling,Zhu Xiangjia,Tham Yih Chung,et al.Prevalence and predictors of myopic macular degeneration among Asian adults: pooled analysis from the Asian Eye Epidemiology Consortium[J].BRITISH JOURNAL OF OPHTHALMOLOGY.2021,105(8):1140-1148.doi:10.1136/bjophthalmol-2020-316648.
APA:
Wong, Yee Ling,Zhu, Xiangjia,Tham, Yih Chung,Yam, Jason C. S.,Zhang, Keke...&Saw, Seang Mei.(2021).Prevalence and predictors of myopic macular degeneration among Asian adults: pooled analysis from the Asian Eye Epidemiology Consortium.BRITISH JOURNAL OF OPHTHALMOLOGY,105,(8)
MLA:
Wong, Yee Ling,et al."Prevalence and predictors of myopic macular degeneration among Asian adults: pooled analysis from the Asian Eye Epidemiology Consortium".BRITISH JOURNAL OF OPHTHALMOLOGY 105..8(2021):1140-1148