Lhasa childhood eye study: the rationale, methodology, and baseline data of a 5year follow-up of school-based cohort study in the Tibetan plateau region of Southwest China
机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Beijing Institute of Ophthalmology, Beijing, China.首都医科大学附属北京同仁医院研究所眼科研究所
BackgroundTibetan Plateau is a highland area with special geographical location, time zone, and ethnic composition. We herein report the rationale, methodology and baseline data of the school-based childhood cohort study named Lhasa Childhood Eye Study (LCES), with the primary objective to pursue a comprehensive understanding on the longitudinal trends of refractive error as well as other ocular diseases and to address the differences between Tibetan Plateau and other parts of the world.MethodsGrade one students from primary schools in Lhasa were cluster randomly selected. They were examined and would be conducted with follow-up annually for 5years. The examination procedures for LCES consisted of standardized ocular, systematic examinations, and questionnaires, identical to the Anyang Childhood Eye Study (ACES) conducted in central China.ResultsOne thousand nine hundred two Grade one students eligible for the LCES, 1856 (97.58%) participated in the study, with a mean age of 6.830.46years (range 5.89-10.32years), and the proportions of male to be 53.02%. 1762 (94.93%) of the 1856 participants in the baseline exam were Tibetans. 1837 (98.98%) of the students examined had cycloplegic autorefraction performed. The numbers of hyperopia, emmetropia, myopia, and high myopia were 127 (6.91%), 1639 (89.22%), 71 (3.86%) and 3 (0.16%) respectively. Compared with ACES, students from LCES baseline had a younger age (p<0.001), lower cycloplegic spherical equivalent (p<0.001), similar myopia prevalence (p=0.886), lower hyperopia prevalence (p<0.001), and a higher emmetropia prevalence (p <0.001).ConclusionsLCES was a school-based cohort study in Tibetan Plateau with a high baseline response rate. A higher emmetropic trend was found in LCES compared with ACES. Continuous documentation of this cohort might potentially provide useful reference information for the areas of China which was previously not well studied.Trial registration p id=Par The study has finished the clinical registration on Chinese Clinical Trial Registry. (ChiCTR1900026693).
基金：
Capital Health Development Special Fund of China -Major Project [SF-2018-1-2051]; Capital Health Development Special Fund of China -Youth Project [2018-4-1083]; High Level Health Technical Talent Training Program of Beijing Municipal Health Bureau [2015-3-023]; Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [Z171100001017066]; Beijing Hoson Foundation
第一作者机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China.[2]Beijing Institute of Ophthalmology, Beijing, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Weiwei,Fu Jing,Meng Zhaojun,et al.Lhasa childhood eye study: the rationale, methodology, and baseline data of a 5year follow-up of school-based cohort study in the Tibetan plateau region of Southwest China[J].BMC OPHTHALMOLOGY.2020,20(1):doi:10.1186/s12886-020-01522-w.
APA：
Chen, Weiwei,Fu, Jing,Meng, Zhaojun,Li, Lei,Su, Han...&Yao, Yao.(2020).Lhasa childhood eye study: the rationale, methodology, and baseline data of a 5year follow-up of school-based cohort study in the Tibetan plateau region of Southwest China.BMC OPHTHALMOLOGY,20,(1)
MLA：
Chen, Weiwei,et al."Lhasa childhood eye study: the rationale, methodology, and baseline data of a 5year follow-up of school-based cohort study in the Tibetan plateau region of Southwest China".BMC OPHTHALMOLOGY 20..1(2020)
