详情页 - 首都医科大学附属北京同仁医院知识库

当前位置：首页 > 详情页

Involvement of Qa-1/HLA-E-Restricted CD8(+) T Cells in Anti-Microbe and Anti-Cancer Immunity as Well as in Immune Regulation

4| 认领 | 导出 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Shanghai Jiao Tong Univ, Tongren Hosp, Sch Med, Shanghai 200336, Peoples R China [2]Takeda Pharmaceut Inc, Cambridge, MA 02142 USA [3]UCSD Sch Med, Dept Med, 9500 Gilman Dr, La Jolla, CA 92093 USA

出处：

ISSN：

关键词： nonclassical MHC CD8 T immune regulatory transcriptional factor

摘要：

The TCR-mediated recognition of self and microbial protein antigens by CD8(+) T cells presented by the relatively nonvariable, class Ib MHC molecule, Qa-1 in mice and HLA-E in humans, is emerging as an important arm of the immune response. In this brief review, we will cover key examples of Qa1/HLA-E-restricted CD8(+) T cells and their role in immunity against microbes and in cancer, but also as an important immunoregulatory pathway complementary to the FoxP3(+)CD4(+) Treg. Although much remains to be learned, increased understanding of HLA-E-targeted immune responses can be potentially exploited in the development of broader and complementary immunotherapeutics against bacteria/viruses, tumors, and autoimmune diseases.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2020]版中科院分区表Review为是的期刊

：

大类 | 4 区医学

小类 | 4 区免疫学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区免疫学

JCR分区：

出版当年[2019]版：

Q4 IMMUNOLOGY

最新[2023]版：

Q4 IMMUNOLOGY

影响因子： 0.8 最新[2023版] 1.7 最新五年平均 1.404 出版当年[2019版] 2.305 出版当年五年平均 1.191 出版前一年[2018版] 2.214 出版后一年[2020版]

第一作者：

第一作者机构： [1]Shanghai Jiao Tong Univ, Tongren Hosp, Sch Med, Shanghai 200336, Peoples R China

通讯作者：

通讯机构： [3]UCSD Sch Med, Dept Med, 9500 Gilman Dr, La Jolla, CA 92093 USA [*1]Vipin Kumar, Dept. Medicine, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases [2]CD3+、CD4+、CD8+T细胞水平在胃癌患者外周血中的变化 [3]Polyvinylpyrrolidone-curcumin nanoparticles with immune regulatory and metabolism regulatory effects for the treatment of experimental autoimmune uveitis [4]外周CD8αα＋TCRαβ＋调节性T细胞表型与功能初步研究 [5]SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8(+)T cells [6]Inhibition of host Ogr1 enhances effector CD8(+) T-cell function by modulating acidic microenvironment [7]Author Correction: GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases [8]DA-DRD5 signaling reprograms B cells to promote CD8+ T cell-mediated antitumor immunity [9]Correction: Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment. [10]Steroids Enable Mesenchymal Stromal Cells to Promote CD8(+) T Cell Proliferation Via VEGF-C