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Polyvinylpyrrolidone-curcumin nanoparticles with immune regulatory and metabolism regulatory effects for the treatment of experimental autoimmune uveitis

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机构: [1]Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, PR China [2]Department of Clinical Medicine, The Second School of Clinical Medicine, Anhui Medical University, Hefei 230032, PR China. [3]Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China. [4]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, PR China. [5]Research Center for Translational Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, PR China [6]School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, PR China.
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关键词: Nanoparticles Curcumin Polyvinylpyrrolidone Experimental autoimmune uveitis EAU Inflammation

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Uveitis comprises a cluster of intraocular inflammatory disorders characterized by uncontrolled autoimmune responses and excessive oxidative stress leading to vision loss worldwide. In the present study, curcumin (CUR) was conjugated with polyvinylpyrrolidone (PVP) to form PVP-CUR nanoparticles with significantly elevated solubility and outstanding multiple radical scavenging abilities. In vitro studies revealed that PVP-CUR nanoparticles markedly mitigated oxidative stress and reduced apoptosis in a H2O2-induced human retinal pigment epithelial cell line (ARPE-19) and promoted phenotypic polarization from M1 to M2 in an LPS-induced human microglial cell line (HMC3). Further in vivo studies demonstrated the prominent therapeutic effects of PVP-CUR nanoparticles on experimental autoimmune uveitis (EAU), which relieved clinical and pathological progression, improved perfusion and tomographic manifestations of retinal vessels, and reduced blood-retinal barrier (BRB) leakage; these effects may be mediated by mitigating oxidative stress and attenuating macrophage/microglia-elicited inflammation. Notably, treatment with PVP-CUR nanoparticles was shown to regulate metabolite alterations in EAU rats, providing novel insights into the potential underlying mechanisms involved. Additionally, the PVP-CUR nanoparticles showed great biocompatibility in vivo. In summary, our study revealed that PVP-CUR nanoparticles may serve as effective and safe nanodrugs for treating uveitis and other oxidative stress- and inflammation-related diseases.Copyright © 2024. Published by Elsevier B.V.

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出版当年[2023]版:
大类 | 1 区 医学
小类 | 1 区 化学:综合 1 区 药学
最新[2023]版:
大类 | 1 区 医学
小类 | 1 区 化学:综合 1 区 药学
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出版当年[2022]版:
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 PHARMACOLOGY & PHARMACY
最新[2023]版:
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 PHARMACOLOGY & PHARMACY

影响因子: 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

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第一作者机构: [1]Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, PR China [2]Department of Clinical Medicine, The Second School of Clinical Medicine, Anhui Medical University, Hefei 230032, PR China.
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通讯机构: [5]Research Center for Translational Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, PR China [6]School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, PR China.
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